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Does anyone know what CD25+ cells are used for?
Hi all,
Prof De Meirleir runs several tests on his patients and one of them includes CD56 cells. If I remember correctly a lower number of CD56 cells is connected to a weaker immune system (like in CFS). But I also found this study which comes to the conclusion that the lower the number of CD56 cells, the higher the symptoms of depression get.
Natural Killer T cells in patients with major depressive disorder.
Park EJ, Lee JH, Chae JH, Lee KH, Han SI, Jeon YW.
Department of Psychiatry, Our Lady of Mercy Hospital, The Catholic University of Korea, #665, Bupyeong 6-dong, Bupyeong-gu, Incheon, 403-720, Republic of Korea.
Abstract
CD56 (Natural Killer T) cells showed a significant negative correlation with depressive symptom scale scores in acute and unmedicated patients with major depressive disorder. Decreased CD56 cells may reflect the severity of depressive symptoms but not the severity of anxiety symptoms in major depression.
PMID: 17027089 [PubMed - indexed for MEDLINE]
CD57+/CD3- ABSOLUTE CELL COUNT (Code: CD57)
Background
CD57+/CD3- cells are a subset of NK cells. Their exact function, and what differentiates them from CD56+ NK cells, is not well understood. The absolute number of CD57+/CD3- cells is low in patients suffering from chronic Lyme disease (a disease that follows an infection by a bacteria called Borrelia). Patients with very low CD57 have significantly more co-infections and persistent immunologic defects than patients with higher counts. In patients that respond to antibiotic therapy, the number of cells come back to normal, hence this is a useful marker to follow the effect of a therapy.
Method
Three color flow cytometry. Whole blood cells are stained with anti-CD57, anti-CD3, anti-CD45 fluorescence-labeled antibodies. Absolute number of CD45+/CD57+/CD3- cells is determined by flow cytometry.
Result
Quantitative. The result gives the absolute number of CD57 positive, CD3 negative cells per l of whole blood. The normal range is 60-360 cells/l.
I changed it. I never wanted to bring up a causality between depression and CD56 cells. Moreover I thought of lower CD56 counts in the first place, which is followed by depression symptoms through some mechanism later.
I really meant the CD56 cells not CD57. Prof De Meirleir tested CD3+CD16CD56+ all together and I'm low. I looked at my test results again.