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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Yes he is listing possibilities.
3) NO gets broken down into peroxynitrite after its job is done. Peroxynitrite is an oxidant (meaning it's potentially harmful in large quantities and in the wrong place).
NO gets broken down into peroxynitrite after its job is done.
I like tot say here:... NO doesn't really have a job; it is produced as a side effect by some reactions, and some other systems evolved to make use of the presence of NO, but a molecule of NO isn't produced with a specific task it is supposed to do.
Seems like this doctors thinking is on par with what I have seen before. Whether they can actually help you depends if you respond to whatever treatment they comes up with. Since you avoid sugar, you are already on the right track. You just never know what might help, we are all so different. ME throws us for a loop, so it really does become a balancing act to try to put things right again.He's an Endocrine/diabetes guy as well as fatigue specialist and obsessed with my glucose even though I've never shown as at risk for diabetes and have a low bmi ear clean and dislike sugary food. What's the odds he tries to get me to go keto. Sigh.
https://www.ncbi.nlm.nih.gov/m/pubmed/15320480/
P8. He says your sleep habits are bad and speculates that correcting this could give you more energy. He prescribed melatonin supplement to help you sleep and is checking your stress hormone cortisol to see if you may have adrenal fatigue.
Yes he is listing possibilities.
In particular I am keen to understand what is meant by
1. Nitric Oxide peroxynite pathway disorders?
2. Underlying methylation pathway?
3. Polymorphism of COMT?
4. What is a cortisol profile?
I'm a bit worried he is focusing on my historic episode...
I'm not honestly sure the NO pathway functions are well enough known to figure this out. All of the reading I've done suggest this pathway is ubiquitous in health and illness, as the article you attach states, If it's everywhere it must be doing something important, but not necessarily the same thing in every cell. This honestly sounds like a bit of a fishing expedition to me- Here's a pathway that's broken in lot's of chronic illness and is involved in most physiologic processes in the body so let's see if it's broken here. I'm curious about the role of the NO pathway in hypoxia and heart failure given Dr. Systrom's findings. That's what seems relevant to me for ME/CFS.All very interesting but doesn't explain what type of disorders of NO path he is contemplating.
https://www.ncbi.nlm.nih.gov/m/pubmed/15320480/