bertiedog
Senior Member
- Messages
- 1,716
- Location
- South East England, UK
It has been shown by several researchers - Dr Lipton comes to mind - that one of the most important Short Chain Fatty Acids (SCFAs) is low in ME and also in other inflammatory bowel conditions, diabetes and other chronic illnesses.
I belong to GeneticsLifehacks who give a weekly round up of various topics and one of the updated ones is on TNF alpha which is an inflammatory cytokine. I don't know if this has been shown to be high in ME, I haven't had time to check but my genetics were shown as follows -
rs1800629 - A/G, also A/A - higher TNF-alpha
Short-chain fatty acids, such as butyrate, are important for colon health. High levels of TNF-alpha decrease the expression of transporters for butyrate (reference supplied.
.
However, the two other SCFAs, acetate and propionate are at good levels in my stool tests so I wonder if this SNP could be the reason why my butyrate is always low despite eating the foods which are supposed to support its production?
I wonder if this SNP rs1800629 which is associated with higher TNF alpha is common in ME which would account for the low butyrate in our illness?
Pam
I belong to GeneticsLifehacks who give a weekly round up of various topics and one of the updated ones is on TNF alpha which is an inflammatory cytokine. I don't know if this has been shown to be high in ME, I haven't had time to check but my genetics were shown as follows -
rs1800629 - A/G, also A/A - higher TNF-alpha
Short-chain fatty acids, such as butyrate, are important for colon health. High levels of TNF-alpha decrease the expression of transporters for butyrate (reference supplied.
.
However, the two other SCFAs, acetate and propionate are at good levels in my stool tests so I wonder if this SNP could be the reason why my butyrate is always low despite eating the foods which are supposed to support its production?
I wonder if this SNP rs1800629 which is associated with higher TNF alpha is common in ME which would account for the low butyrate in our illness?
Pam