Breakthrough in Prostate Cancer research

acer2000

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Researchers in Cork say they have created a vaccine which could in the future be used to effectively protect against prostate cancer.

The Cork Cancer Research Centre at University College Cork says it has identified DNA vaccines that are able to target and destroy cancer cells.

http://www.rte.ie/news/2010/0205/cancer.html

Could be interesting given the association with XMRV and certain prostate cancers.
 

Andrew

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Amazing stuff. Thanks for posting this.

FWIW, there is a little loudspeaker icon in the upper left corner of the article. Click it and you can hear an interview with one of the researchers.
 

liverock

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Inositol hexaphosphate(IP6)a natural product found in rice bran, has been found to kill prostate cancer cells.

Could it also I wonder, kill the dreaded XMRV ?

http://www.ncbi.nlm.nih.gov/pubmed/...nel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice.
Raina K, Rajamanickam S, Singh RP, Agarwal R.

Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, Denver, Colorado 80262, USA.

PURPOSE: Herein, for the first time, we evaluated the in vivo chemopreventive efficacy of inositol hexaphosphate (IP6), a major constituent of high-fiber diets, against prostate tumor growth and progression in the transgenic adenocarcinoma of the mouse prostate (TRAMP) model.

EXPERIMENTAL DESIGN: Beginning at 4 weeks of age, male TRAMP mice were fed 2% (w/v) IP6 in drinking water or only drinking water till 24 weeks of age, and then sacrificed. Prostate tissue was subjected to histopathologic analysis and to immunohistochemical analyses for proliferation and apoptosis.

RESULTS: IP6 feeding did not show any adverse effect on fluid and diet consumption and body weight. There was a significant reduction (40%; P < 0.01) in lower urogenital tract weight in IP6-fed mice. IP6 inhibited prostate cancer progression at prostatic intraepithelial neoplasia stage and strongly reduced the incidence of adenocarcinoma (prostatic intraepithelial neoplasia/adenocarcinoma, 75:25% in the IP6 group versus 39:61% in the control group; P < 0.05). The incidences of well-differentiated and poorly differentiated adenocarcinomas in the IP6-fed group were reduced by 44% and 62%, respectively. Immunohistochemical analysis of prostate tissue showed a 26% decrease (P < 0.05) in proliferation cell nuclear antigen-positive cells and a 3.5-fold increase in apoptotic cells with no effect on Tag expression by IP6.

CONCLUSIONS: These findings are both novel and highly significant in establishing for the first time that oral IP6, without any toxicity, suppresses prostate tumor growth and progression at the neoplastic stage, thereby reducing the incidence of adenocarcinoma through its antiproliferative and proapoptotic effects, and thus indicating that IP6 could have potential chemopreventive effects against human prostate cancer.

PMID: 18483386 [PubMed - indexed for MEDLINE]
 

Alesh

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It is perhaps an inappropriate digression from the main theme of this thread but I remember having read in some official general survey of cancer incidence in the USA that there was an inexplicable increase of prostate cancer in the 1990s. I wonder if there might be a relation to a putative XMRV onset of spread in the 1980s and the first cases of CFS documented by Fukuda et al.