http://www.mefmaction.net/Portals/0/docs//Blood Transfusions and CFS.pdf
From: Legal Disability Manual for Fibromyalgia Syndrome and Myalgic Encephalomyelitis/Chronic
Fatigue Syndrome Editor: Marjorie van de Sande, National ME/FM Action Network
FMS & ME/CFS Overview
Blood Transfusion and Chronic Fatigue Syndrome
K. De Meirleir, P. De. Becker, I. Campine.
Human Physiology and Medicine
Vrije Universiteit Brussel, Brussels, Belgium
Reprinted with permission from Dr. De Meirleir
Presented at the Sydney February 1999 CFS Conference.
We analysed the data of 1210 consecutive patients complaining of chronic
fatigue who visited our fatigue clinic at the Vrije Universiteit Brussel.
In this group, 752 patients fulfilled the CDC criteria for CFS (Fuduka, 1994). Of
those CFS patients, 34 (4.5%) have a common factor in their past medical history
that immediately preceded the onset of their CFS. These patients had received a
blood transfusion a few days to a week prior to developing a flu-like syndrome
that later proved to be the acute onset of their CFS. Another 8 patients also
received a blood transfusion but their illness only started at least two months
later, so that we cannot take these patients into our calculations.
None of these post-transfusion patients developed hepatitis C or other types of
viral hepatitis. Some have antibodies (IgG) in time relationship to the blood
transfusion could not be determined. In 9 of 35 patients the LMW RNase L
account for the upregulation of the total RNase L enzyme activity. This 2-5A
synthetase Rnase L pathway is activated in viral disorders.