Blood test interpretation (high IL-10)

crypt0cu1t

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I had an opportunity to have a proinflammtory cytokine panel done to figure out the cause of my high ESR/CRP.

I was expecting more cytokines to be elevated, but the only one that was high was IL-10. Does anyone know the function of IL10 or if this could help me determine the source of my inflammation?
 

vision blue

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I thought IL-10 was one of the good guys but it's been a while since i've checked and i guess everything is a double edged sword. One thing you want to look up is if that suggests you are leaning towards th1 or th2. YOu should be able to find that easy enough.

At least you had something show up on your cytokine panel. All of mine were within range. Which was your lab? Mine was sent to ARUP. If it was a differnt lab, do your reference ranges have lower limits or just upper limits? I.e. on mine, normal range was listed as less than or equal, so for IL 10, normal range was less than or equal 5 and my value just listed as less than 5.

Could you check your value at "IL 2 receptor (CD 25)"? That was the only one of mine with an actual number , 380, and with ref range as less than 1035 or something like that being normal.

I always run very low crp though even when deathly ill.

I would also be interested to know if you had it done at the lab where it was analyzed or you used a local draw station that then sent it over.
 

crypt0cu1t

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I thought IL-10 was one of the good guys but it's been a while since i've checked and i guess everything is a double edged sword. One thing you want to look up is if that suggests you are leaning towards th1 or th2. YOu should be able to find that easy enough.

At least you had something show up on your cytokine panel. All of mine were within range. Which was your lab? Mine was sent to ARUP. If it was a differnt lab, do your reference ranges have lower limits or just upper limits? I.e. on mine, normal range was listed as less than or equal, so for IL 10, normal range was less than or equal 5 and my value just listed as less than 5.

Could you check your value at "IL 2 receptor (CD 25)"? That was the only one of mine with an actual number , 380, and with ref range as less than 1035 or something like that being normal.

I always run very low crp though even when deathly ill.

I would also be interested to know if you had it done at the lab where it was analyzed or you used a local draw station that then sent it over.
Yeah, it's a bit strange considering I have a constantly elevated ESR/CRP. It makes me wonder if it's just my body trying to dampen down the inflammation. As for the level, the reference range is 2.8 and my level was 3.5

My IL 2 Receptor level was 771.2 with a cutoff at 858. I'm not too sure what exactly this means.
 

sometexan84

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I had same result. I'll share what I have, it's not much....

High IL-10 associated w/

• Lymphocytic Choriomeningitis Virus
o Plasmodium falciparum (Parasite)
• Rheumatoid Arthritis
• Systemic lupus erythematosus (SLE)
• Scleroderma (Systemic Sclerosis)
• Kawasaki disease

IL-10
Cytokine that suppresses IFN-γ secretion in CD8+ TILs. IL-10 blockade enhances the effects of anti-PD-1 therapy in expanding antigen-specific CD8+ T cells.

• CVB4 is dependent on IL-10 for persistent viral infection.

o Lytic EBV reactivation causes inflammatory cytokines: interleukin-6 (IL-6), IL-8, IL-10, and IL-13

May want to read this - The Role of IL-10 in Autoimmune Pathology
 

crypt0cu1t

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I had same result. I'll share what I have, it's not much....

High IL-10 associated w/

• Lymphocytic Choriomeningitis Virus
o Plasmodium falciparum (Parasite)
• Rheumatoid Arthritis
• Systemic lupus erythematosus (SLE)
• Scleroderma (Systemic Sclerosis)
• Kawasaki disease

IL-10
Cytokine that suppresses IFN-γ secretion in CD8+ TILs. IL-10 blockade enhances the effects of anti-PD-1 therapy in expanding antigen-specific CD8+ T cells.

• CVB4 is dependent on IL-10 for persistent viral infection.

o Lytic EBV reactivation causes inflammatory cytokines: interleukin-6 (IL-6), IL-8, IL-10, and IL-13

May want to read this - The Role of IL-10 in Autoimmune Pathology
Have you tested positive for any other autoantibodies since we last spoke?
 

sometexan84

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Have you tested positive for any other autoantibodies since we last spoke?
Nothing since my TS-HDS IgM AB.

I sort of slowed down on autoantibody testing since then. I'm just not sure if finding more antibodies will change my treatment plans at all. Especially if I end up doing IVIG.

If I do more AB testing, these are at the top of my list...
  • Gliadin
  • Intrinsic Factor
  • C1q
 

vision blue

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Y As for the level, the reference range is 2.8 and my level was 3.5

My IL 2 Receptor level was 771.2 with a cutoff at 858. .
Thanks. Do you mean reference range e was <2.8 or was there a range like 1.0-2.8?
And same for the other one- was the range <858 or someting like 200-858?

The reason i asked about the lab is that I think this requires careful specimin handling and I"m pretty sure my lab is too busy and is not very careful. That combined with several hops before it got to ARUP makes me wonder about quality.

Plus curious if labs other than ARUP do this.

with always elevated SED etc, I'd recommend getting your immunuglobulins checked so you can see if it's IgG that's elevated or something else. (and of course a zillion other recommendations!)