adreno
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Have you tried piracetam for comparison?
Blood doping, it helps naughty athletes, could it help us?
- Thread starter AdamS
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Yeah I went through a racetam sample pack. Piracetam wasn't that helpful but it did help mental work in non-sustainable super high dose. The only racetam I liked was Aniracetam, but it's unclear as to why it helps (it's an AMPA activator in research but resource claimed it doesn't absorb properly for this, so I don't know). It's total crapshoot, but they're not worthless for brain problems. Not aware if relation to HIF-1.
For something more constructive, here's an article about methylene blue, I been eying MB for ages but still haven't tried it: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504792/ (this relates to oxygenation mostly)
But when put into context HIF-1 is really only good to increase in stress situations to prevent a relatively worse state. So none of this appeals to me. (the MB has other unrelated effects, pretty sure you know about it)
But when put into context HIF-1 is really only good to increase in stress situations to prevent a relatively worse state. So none of this appeals to me. (the MB has other unrelated effects, pretty sure you know about it)
On the other hand, I suppose, if you do have oxygenation or other problems, particularly in the brain, then temporary HIF-1 increase might be a stepping stone toward better, in fact that might be quite logical. It's just I don't want to setup shop in a staircase.
kangaSue
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That may be the case but the mechanisms of oxygen extraction are also involved here and can influenced by a low oxygen tension too which in turn, can be reduced as the result of hypoxia set off by inflammation or even stress. Hypoxia from transient ischemia is implicated in ME/CFS too.
https://www.healthrising.org/blog/2...l-ischemia-key-pots-chronic-fatigue-syndrome/
[Shungu’s findings of increased lactate and reduced glutathione in the brains of ME/CFS patients fit a scenario in which reduced blood flows (i.e. transient ischemia) to the brain causes increased oxidative stress which in turn knocks out the mitochondria. (Ischemia or low blood flows causes rapid increases in oxidative stress, which in turn can harm the mitochondria). Note that a similar explanation could apply to reduced oxygen delivery to the muscles in ME/CFS.]
If looking for something that has potential to address defects in oxygen supply from any of this, I suggest looking into cilostazol, a peripheral artery vasodilator.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145952/
https://www.ncbi.nlm.nih.gov/pubmed/21963837
I also tried the sample pack (basic and advanced), ani is my favorite of the 8.
kangaSue
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Re mechanism of aniracetam;
https://examine.com/supplements/piracetam/
[In regards to the mechanisms of Piracetam, I am personally leaning more towards Piracetam being an agent that can preserve mitochondrial membrane potential.
This sort of downplays it from a cognitive enhancer to a cognitive preserver. It does interact with mechanisms that can induce cognitive enhancement in otherwise healthy persons (AMPA modulation and Calcium Channel inhibition) but these effects, at best, are weak. Other racetams are more likely to be cognitive enhancers (For AMPA modulation and Calcium channel 2.2 inhibition respectively; this would be Aniracetam and Leviracetam) If it does enhance cognition significantly, it is possible that this is just from reversing small states of cognitive deficit.]
adreno
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Thanks for posting... I did see their article on aniracetam before. There's a section on absorption, but all they say is that it gets rapid elimination by liver.
There was another source somewhere, I can't find it now, that claimed the gut caused conversion of aniracetam into other substances, such that oral use might be completely misleading, whereas if you inject it into the CNS intact, it's actually a reference AMPA activator.
My own experiences with it are good, but inconsistent, so I don't know what to believe. Sometimes it helps me sleep, which is not very intuitive.
Yeah during hypoxia Akt and mTor increase HIF-1. The part I don't completely follow are the effects under non-hypoxia.
adreno
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That's good to know.
This is 100% correct. Man, even collegiate athletes dope and powerlifters (a sport with no money) has tons of doping going on at the world level.
IMO, drugs should be legalized in the olympics to make it an even playing field because as of right now it's not fair. You cannot and will not ever stop drug use in athletics, let alone in society.