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Best antiviral for HHV-7?

H

Hubris

Messages
87
I have very high HHV-7 PCR, so the virus is definitely in the blood and replicating. I doubt there is any way to know for sure if its relevant to my illness(i'm not immunosuppressed as T cell panel is normal but i do have hypogammaglobulinemia) but maybe i could try an antiviral and see if it works - which one would it be?

I'm still waiting on the results of VZV and a few other, if i get another positive i will update the thread but assuming it's just HHV-7 what would be the best antiviral? Valgancyclovir or valacyclovir would not work. In this case https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548691/ they used Acyclovir but from what i understand it doesn't seem to work that well. What alternatives are there?

"Acyclovir was also used as a treatment for possible herpes simplex encephalitis, but this approach remains controversial because acyclovir and other thymidine kinase-dependent drugs are only marginally effective against HHV-7 (21). "

@Hip @Pyrrhus
 
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H

Hubris

Messages
87
Hip said:
By some pharmacokinetic calculations I did, I believe the intravenous antivirals cidofovir (Vistide) and foscarnet (Foscavir) should be potent antivirals for HHV-7. See this post.
Click to expand...
Thank you Hip! Would you be willing to post this calculations? I'm sure it will be impossible to convince a doctor without those...
 
Hip

Hip

Senior Member
Messages
17,874
Hubris said:
Thank you Hip! Would you be willing to post this calculations? I'm sure it will be impossible to convince a doctor without those...
Click to expand...

I don't think the calculations of an amateur like me will be sufficient to convince a doctor. You would really need a published study. The calcs (which are not quite finished) are in a large table, which I can't post on the forum, as it does not support tables. I am trying to set up that table on another external website, but it's taking time to do that.



I know that some of the ME/CFS doctors do test and treat HHV-7, and so they might have clinical knowledge regarding the efficacy of cidofovir or foscarnet for HHV-7. Dr Dan Peterson is the ME/CFS doctor who I think has the most experience with these two antivirals.

In this presentation by Peterson, he mentions that HHV-7 can be treated with antivirals, but does not specify which.
 
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