BCG vaccination hypothesis

[Husband of]

https://www.kinder-verstehen.de/wp-content/uploads/BCG_hypothesis_short_251222.pdf

HYPOTHESIS: The Bacillus Calmette–Guerin (BCG) vaccine has notable “trained immunity” effects and was shown to have therapeutic effects in autoimmune diseases like type 1 diabetes (T1D) and Multiple Sclerosis (MS). This most commonly used vaccine worldwide may also be a treatment option for Post Covid Syndrome (PCS) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

 

[mattie]

Should be fairly easy to test.
In the Netherlands you can get the vaccine when travelling to countries with high tuberculosis incidence.

 

[mitoMAN]

Should be fairly easy to test.
In the Netherlands you can get the vaccine when travelling to countries with high tuberculosis incidence.

you will need 3 vaccines within a year.
I just got my first

 

[pattismith]

https://www.kinder-verstehen.de/wp-content/uploads/BCG_hypothesis_short_251222.pdf

HYPOTHESIS: The Bacillus Calmette–Guerin (BCG) vaccine has notable “trained immunity” effects and was shown to have therapeutic effects in autoimmune diseases like type 1 diabetes (T1D) and Multiple Sclerosis (MS). This most commonly used vaccine worldwide may also be a treatment option for Post Covid Syndrome (PCS) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

BCG vaccine also has a metabolic beneficial effect on Diabetes, so its positive action may be from it's metabolic activity!

BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes - ScienceDirect
2020

Highlights

•
T1D has insufficient aerobic glycolysis; this causes insufficient sugar utilization
•
BCG vaccine lowers blood sugar levels in T1D by augmenting aerobic glycolysis
•
BCG-induced shift to aerobic glycolysis is associated with Myc activation

Summary

Myc has emerged as a pivotal transcription factor for four metabolic pathways:
aerobic glycolysis, glutaminolysis, polyamine synthesis, and HIF-1α/mTOR.

Each of these pathways accelerates the utilization of sugar.

The BCG vaccine, a derivative of Mycobacteria-bovis, has been shown to trigger a long-term correction of blood sugar levels to near normal in type 1 diabetics (T1D).

Here we reveal the underlying mechanisms behind this beneficial microbe-host interaction.

We show that baseline glucose transport is deficient in T1D monocytes but is improved by BCG in vitro and in vivo. We then show, using RNAseq in monocytes and CD4 T cells, that BCG treatment over 56 weeks in humans is associated with upregulation of Myc and activation of nearly two dozen Myc-target genes underlying the four metabolic pathways.

This is the first documentation of BCG induction of Myc and its association with systemic blood sugar control in a chronic disease like diabetes.

Myc

, also known as c-Myc, is a family of regulator genes that code for transcription factors that play a major intracellular role in glucose homeostasis (Lewis et al., 1997).

Myc's pivotal role in the control of sugar metabolism first emerged as central target genes were identified in sugar transport and glycolysis, such as involvement of lactate dehydrogenase (LDH) (Ramanathan et al., 2005, Shim et al., 1997).

Myc-regulated glycolysis utilizes lactate dehydrogenase A (LDHA), which converts pyruvate to lactate as part of the glycolytic pathway.

This research evolved into the subsequent identification of 20 putative Myc target genes in the glycolysis pathway (Dang et al., 2009).

Myc upregulates glucose transporter GLUT1, hexokinase 2 (HK2), phosphofructokinase (PFKM), and enolase 1 (ENO1) (Osthus et al., 2000).

Through upregulation of these genes, Myc was effectively contributing heavily to the entire direct multistep process of aerobic glycolysis, a high cellular glucose utilization state.

It is now appreciated that Myc is so central to aerobic glycolysis that nearly all genes encoding glycolytic enzymes are direct Myc targets and are under Myc control

 

[Forummember9922]

you will need 3 vaccines within a year.
I just got my first

I guess it would be premature to ask how you are doing?

 

[Haley]

Interesting. I had the BCG vaccine in 2001 (working in health in an area with relative high TB rates). I was in the last university graduate cohort where it was given though, because the side effects didn't warrant the mandatory vaccinations.

 

[Forummember9922]

Interesting. I had the BCG vaccine in 2001 (working in health in an area with relative high TB rates). I was in the last university graduate cohort where it was given though, because the side effects didn't warrant the mandatory vaccinations.

Was there any correlation with symptom worsening or improvement for you around 2001?

 

[Haley]

Was there any correlation with symptom worsening or improvement for you around 2001?

Sorry, been out of action for a while.

No, I didn't develop ME/CFS until 2013.

 

[godlovesatrier]

@mitoMAN did you dose regularly with bcg either every month or every 2 weeks as per the healthrising remission article?