I'm so weak right now, but I will try to be detailed.
Having an IBD (ulcerative colitis) flare. Coming out the other end of it, but it's been a rough go. Got an e. coli infection that took almost a month to properly diagnose (bad healthcare system). It did some real damage to my gut in the mean time.
Long story short... on 40mg prednisone (corticosteroid). I really desperately need help preserving my body while on this stuff. The atrophy to my body gets extreme, especially in the arms and legs. My skeleton is already compromised according to DEXA. I used to take high dose curcumin so that I didn't have to take as much prednisone, but then I found out that it was chelating all the iron out of my body and I became extremely anemic. So, no more curcumin for me.
My usual strategy is to take 50mg DHEA and 100mg pregnenolone on every day that I take prednisone. It helps preserve body weight, muscle, and some adrenal functions. But I don't feel like it's the total picture. Pregnenolone is a top of the adrenal cascade, but the adrenals have to be doing the actual conversion for it to be worthwhile, and if the adrenals are offline due to steroids, then I don't know if the conversion is even happening. I don't know enough about the science of it to know of corticosteroids even stop the adrenal precursors from converting.
i.e. while I'm prednisone, if I dump 100mg of pregnenolone in the body, does it become other hormones or does it remain pregnenlone?
DHEA does seem to help directly. I maintain some muscle tone and, god willing, maybe some bone density.
My MD is pretty useless in this department. She doesn't know about hormone anything, and the endocrinologist I went to said "I don't know anything about pregnenolone so you're on your own with that one." This is the top endo in my city.
If someone here could give some recommendations, I will take them and do more research. TIA
Having an IBD (ulcerative colitis) flare. Coming out the other end of it, but it's been a rough go. Got an e. coli infection that took almost a month to properly diagnose (bad healthcare system). It did some real damage to my gut in the mean time.
Long story short... on 40mg prednisone (corticosteroid). I really desperately need help preserving my body while on this stuff. The atrophy to my body gets extreme, especially in the arms and legs. My skeleton is already compromised according to DEXA. I used to take high dose curcumin so that I didn't have to take as much prednisone, but then I found out that it was chelating all the iron out of my body and I became extremely anemic. So, no more curcumin for me.
My usual strategy is to take 50mg DHEA and 100mg pregnenolone on every day that I take prednisone. It helps preserve body weight, muscle, and some adrenal functions. But I don't feel like it's the total picture. Pregnenolone is a top of the adrenal cascade, but the adrenals have to be doing the actual conversion for it to be worthwhile, and if the adrenals are offline due to steroids, then I don't know if the conversion is even happening. I don't know enough about the science of it to know of corticosteroids even stop the adrenal precursors from converting.
i.e. while I'm prednisone, if I dump 100mg of pregnenolone in the body, does it become other hormones or does it remain pregnenlone?
DHEA does seem to help directly. I maintain some muscle tone and, god willing, maybe some bone density.
My MD is pretty useless in this department. She doesn't know about hormone anything, and the endocrinologist I went to said "I don't know anything about pregnenolone so you're on your own with that one." This is the top endo in my city.
If someone here could give some recommendations, I will take them and do more research. TIA