B6 reaction

[Tiger Lily 813]

Just tried p5p sublingual tablet of B6 yesterday (17 mg) as it keeps getting recommended in articles I was reading about lowering estrogen and supporting fertility and when I took it, I felt really tired and relaxed and that was fine, but the next morning, my skin and eyes are so dry and I feel like I did not sleep.
Did B6 end up lowering something else? That is why I don't usually take individual vitamins...
I don't want to take it again now, obviously too much for me in some way, but would like to know how to regain homeostasis for now. I appreciate your help!

 

[NameHere]

My body doesn't tolerate vitamin supplements anymore; they cause extreme fatigue, brain fog and dizziness. Also when I was taking B6 several years ago, I got hypervitaminosis, proven by a blood test. When I stopped that and all my other vitamins, there was an improvement in my health. You gotta watch out for the doses that go way above the RDA (recommended daily allowance).

The half life of Vitamin B6 is 20-30 days; so that means in 20-30 days, your body will have gotten rid of half of the B6 that you supplemented. You just have to wait for the effects to wear off.

 

[linusbert]

vitamin b6 is a heavy hitter in regards of your neuro transmitters, if you are new to it, its better to take once a low dose per week and go up from there. but i would always add a multivitamin in regards of imbalances.
i can take a b complex and be fine, but any isolated vitamins especially b2 and b6 in the same dose will cause problems, for me its for b6 kinda insanity, i get angry so fast i feel like a mad man, where i am usually a calm dude.
b2 makes me light sensitive and increases somehow migraine potential.

 

[Tiger Lily 813]

My body doesn't tolerate vitamin supplements anymore; they cause extreme fatigue, brain fog and dizziness. Also when I was taking B6 several years ago, I got hypervitaminosis, proven by a blood test. When I stopped that and all my other vitamins, there was an improvement in my health. You gotta watch out for the doses that go way above the RDA (recommended daily allowance).

The half life of Vitamin B6 is 20-30 days; so that means in 20-30 days, your body will have gotten rid of half of the B6 that you supplemented. You just have to wait for the effects to wear off.

Ugh, well, thanks so much for letting me know! I thought that b's being water-soluble meant it would not be long to pedal back from what I take, so thank you for explaining that. I appreciate your help!

 

[Tiger Lily 813]

vitamin b6 is a heavy hitter in regards of your neuro transmitters, if you are new to it, its better to take once a low dose per week and go up from there. but i would always add a multivitamin in regards of imbalances.
i can take a b complex and be fine, but any isolated vitamins especially b2 and b6 in the same dose will cause problems, for me its for b6 kinda insanity, i get angry so fast i feel like a mad man, where i am usually a calm dude.
b2 makes me light sensitive and increases somehow migraine potential.

Yeah, the same amount of b6 that I took is in the multi I take most days no issue, but this separate b6 was p5p form, so maybe something to do with that. So yes, I am going back to my multi to hopefully get back to normal soon! Sometimes vitamins/supplements are being marketed so willy nilly these days that I forget how impactful they are. I need to approach anything new as a potential risk and experiment! Thank you so much for your insight!!

 

[datadragon]

Yeah, the same amount of b6 that I took is in the multi I take most days no issue, but this separate b6 was p5p form, so maybe something to do with that.

P5p is the active form. See if you can try say 1/10 the tablet to get closer to an RDA level to see if it causes the issues still for you.

Be careful of using pyridoxine. Supplementation with high concentrations of the pyridoxine form only of Vitamin B6 competitively inhibits the active Pyridoxal 5' phosphate (P5P) form which actually leads to decreased vitamin B6 function (deficiency) rather than enhancing it. Also, Pyridoxine is shown to also be the toxic form of vitamin B6 so care to avoid higher doses.
https://pubmed.ncbi.nlm.nih.gov/28716455/
Vitamin B6 normally needs Zinc, Magnesium, and Vitamin B2 (flavin mononucleotide (FMN); also known as riboflavin-5’-phosphate) in the conversion to active B6 (P5P).
My guess is that the b6 isn’t gettting into the cell and utilized during inflammation in this case, leading to higher serine that may cause the dry eye
https://pmc.ncbi.nlm.nih.gov/articles/PMC7560718/
https://pubmed.ncbi.nlm.nih.gov/28801717/
B6 into cell
https://forums.phoenixrising.me/threads/iodine-protocol-any-experiences.92586/post-2467019

 

[pamojja]

Also when I was taking B6 several years ago, I got hypervitaminosis, proven by a blood test.

As soon as one supplements B6, in your case with probably the problematic pyridoxine, serum B6 tests will show high, even though the measured pyridoxine is the inactive and unmetabolized form of vitamin B6, and therefore still deficient in. Despite the high serum levels. Same with B9 or B12, for example.

Pyridoxine form of B6 isn't tolerated well, some can take none of it, I tolerated it up to 100 mg/d, before it caused neuropathy for me. A side effects, which both can come from deficiency of vitamin B6, and very often from supplementing the wrong pyridoxine form of vitamin B6.

For me the neuropathy ceased after supplementing the right form of P-5-P, Pyridoxal-5-phosphate, at about 130 mg/d for a year. When only a sign of vitamin B6 sufficiency, remembering dreams, returned.

 

[datadragon]

Pyridoxine form of B6 isn't tolerated well, some can take none of it, I tolerated it up to 100 mg/d, before it caused neuropathy for me. A side effects, which both can come from deficiency of vitamin B, and very often from supplementing the wrong pyridoxine form of vitamin B6.

For me the neuropathy ceased after supplementing the right form of P-5-P, Pyridoxal-5-phosphate, at about 130 mg/d for a year. When only a sign of vitamin B6 sufficiency, remembering dreams, returned.

Some people mention a lack of dreaming. Back in the 1970s a doctor named Cal c pfeiffer PhD MD mentioned that Vitamin B6 is responsible for lucid dreaming to remember them. Originally I thought the lack of nutrients like magnesium, zinc, and even B2 might have kept the conversion of B6 from happening to the active P5P form and may therefore start to remember dreams when B6 is adequate. Later we also learned from research above that supplementation with high concentrations of the pyridoxine form of Vitamin B6 competitively inhibits the active Pyridoxal 5' phosphate (P5P) form which actually leads to decreased vitamin B6 function and deficiency rather than enhancing it.. so that can be why that form isn’t helping fix a deficiency in some cases. https://www.sciencedirect.com/science/article/abs/pii/S0887233317301959?via=ihub

However most recently it appears that zinc and magnesium are cofactors that also are needed for B6 entry into the cell I found as well, so zinc and magnesium deficiency/unavailability may further impair utilization of vitamin B6 during inflammation/infection states even when supplementing such as using the active form P5P. This may be why B6 levels become high instead during that time fueling serine. https://forums.phoenixrising.me/thr...duction-utilization.57030/page-3#post-2440317

 

[NameHere]

As soon as one supplements B6, in your case with probably the problematic pyridoxine, serum B6 tests will show high, even though the measured pyridoxine is the inactive and unmetabolized form of vitamin B6, and therefore still deficient in. Despite the high serum levels. Same with B9 or B12, for example.

Pyridoxine form of B6 isn't tolerated well, some can take none of it, I tolerated it up to 100 mg/d, before it caused neuropathy for me. A side effects, which both can come from deficiency of vitamin B, and very often from supplementing the wrong pyridoxine form of vitamin B6.

For me the neuropathy ceased after supplementing the right form of P-5-P, Pyridoxal-5-phosphate, at about 130 mg/d for a year. When only a sign of vitamin B6 sufficiency, remembering dreams, returned.

It had both forms of B6. I was taking it in a multi called "Two Per Day," but I only took "One" per day because it contained ridiculously high levels of vitamins already in just "One."

So here's what I was getting per day: (this is 28 times RDA):

Vitamin B6 (as pyridoxine HCI, pyridoxal 5’-phosphate)

37.5 mg​

I took this off and on for a few years. At this level I experienced these symptoms which increased over time while taking this supplement: extreme dizziness, a feeling of being out of my body, a feeling of being high, when I went to the bathroom the color in the toilet was neon yellow--none of it was pleasant. Upon stopping the multivitamin completely, all those symptoms gradually stopped, except for dizziness, which went down to a lower baseline. Because this supplement contained both forms, it is not the case that one form was blocking the other one resulting in a deficiency.

Apparently, supplementing with high doses of B6 can cause permanent damage.

"There are theories when this happens over long periods of time it can cause irreversible damage to the extent you may find it difficult to walk or find balance," https://www.abc.net.au/news/2025-01...heral-neuropathy-health-supplements/104793006

So, it is not possible to convince me that super high doses of any vitamin is healthy or risk-free, especially in the absence of objective proof that the vitamin(s) are in a state of deficiency in the body.

For those claiming that harm only comes from pyridoxine but not the other form, I'm here to tell you I was harmed by both, likely due to the dose and the length of time supplemented.

 

[pamojja]

For those claiming that harm only comes from pyridoxine but not the other form, I'm here to tell you I was harmed by both,

You can't be sure of that. As I said, some here on this forum, tolerate not even a milligram of pyridoxine, I always took 1 Two-per-day, and added some from their full LifeExtension mix multi (with both forms of B6 too). In my case, I tolerated up to 80 mg/d pyridoxine just fine, only above 100 mg/d caused reversible neuropathy. If you search the literature, you'll find only the pyridoxine form causing neuropathy.

So when I said I increased to 130 mg/d of P-5-P, during that time my pyridoxine intake was still about 40-50 mg/d at the same time. In my case, not harming at all. But as said, others are more sensitive and have difficulty with any slight amount of pyridoxine.

extreme dizziness, a feeling of being out of my body, a feeling of being high, when I went to the bathroom the color in the toilet was neon yellow--none of it was pleasant. Upon stopping the multivitamin completely, all those symptoms stopped, except for dizziness, which went down to a lower baseline.

A multi, like Two-per-day with over 30 declared, has many ingredients. Where any of them might cause a imbalance of nutrients in your case, responsible for your symptoms. The yellow for example comes from riboflavin, B2. Which I personally never felt unpleasant. On the contrary, motivated to mitigate dehydration better.

So, it is not possible to convince me that super high doses of any vitamin is healthy or risk-free, especially in the absence of objective proof that the vitamin(s) are in a state of deficiency in the body.

I don't want to convince you, if you're not accessible to the given reasons. But I do try to balance onesided perspectives on health forums. For the benefit of others reading.

Real nutrients overload or deficiency cause real health problem. For one's own health benefits, one better finds those objective proofs, that is time to adjust doses. Not only dirct nutrient lab tests, which in the case of supplementing B-vitamins become unrelyable, but also all other symptoms and lab-tests, showing imbalances downstream to other metabolic systems.

 

[Carl]

Just tried p5p sublingual tablet of B6 yesterday (17 mg) as it keeps getting recommended in articles I was reading about lowering estrogen and supporting fertility and when I took it, I felt really tired and relaxed and that was fine, but the next morning, my skin and eyes are so dry and I feel like I did not sleep.
Did B6 end up lowering something else? That is why I don't usually take individual vitamins...
I don't want to take it again now, obviously too much for me in some way, but would like to know how to regain homeostasis for now. I appreciate your help!

Metabolics and Epigenetics both sell liquid P-5-P and R-5-P and I have used both. These allow adjustment of the dosage more easily. I currently use the metabolics P-5-P form and Epigenetics R-5-P form. They do a few different varieties of both in different strengths and formulas. The Metabolics P-5-P form that I am currently using has 848 ug/drop whereas the Epigenetics lowest strength has 0.23mg/drop 230ug/drop, The Epigenetics Super P5P has 3mg/drop for people who need higher amounts.
Metabolics Vitamin B6 (Pyridoxal-5-Phosphate)
Epigenetics Vitamin B6 (Pyridoxal-5-Phosphate)
I stick to the ones with the least amount of "extras" such as Glycerine which is in the Epigenetics Linctus form.