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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Niacin seriously increased my general symptoms, and added strong suicidal moods. B2 also increased my symptoms, though not as much as B3. B12 also triggered strong suicidal moods. It did so for several tries, but when I tried it again months later, it didn't have that effect. A change in my body, or do B12 tablets expire quickly?
B1 seemed to reduce symptoms slightly, but only the first few times I tried it.
My guess is homocysteine is too low,
@jwat87 , I took basic cyanocobalamin, 1200 mcg. It's three years past the expiry date, so I don't know how effective it is now. It certainly caused serious problems when it was fresh.
I've ignored the topic of methylation. It seems like a health fad: overmarketed without serious numbers to back up the claims. B12 didn't do anything for my ME symptoms, so I didn't feel any urge to consider it any further. My leafy-green intake varies with the seasons, and I didn't notice any correlation with my symptoms, so I don't consider that as a likely factor either.