"Our working hypothesis is that immune dysfunction associated with inflammation of the intestinal mucosa leads to the introduction of bacterial components, including neurotoxins,
into the bloodstream, creating oxidative stress as well as microvascularities, especially affecting meningeal vessels and finally specific neuronal damage.
"
In the case of ME and CFS we have lipopolysaccharides in our blood, but I do not recall seeing this paper published yet (by KDM). There may indeed be a case here, but so far there has been little published. We need these people to publish - one of the issues that is happening I think is that everyone is trying to publish in higher prestige journals, and work their way down till they get accepted. This slows down the research cycle, so its debatable if publishing in high prestige journals is worth it, particularly if they are behind paywalls.High levels of LPS in us should induce toxic shock - but instead we get a different reaction. If that can be confirmed it is certainly very interesting: I wonder if the issue might be different bacterial toxins in different neuroimmune diseases?
All this is very interesting, but we still need more published.
Bye, Alex