Widen that net even further, because mitochondrial function doesn't just depend on mtDNA, it also depends on nuclear DNA, since production of many proteins critical for mt function have been outsourced to the nucleus. Not only do the genes have to work correctly, they have to match up properly. You can have have a gene scan showing mtDNA and nuclear DNA both showing perfect function ... yet the mitochondria don't work well because it's the wrong match-up of perfect genes, and we don't yet know what matches are good.
The question on my mind is: will medical AI figure out how to figure out all the intricacies of human biology before AI out-evolves humanity?
