Artificially induced fever

Messages
14
Likes
27
Hi, since my ME/CFS Symptoms startet 2 years ago I was sick and had infections multiple times, without ever getting a fever- even tough this would be the body's natural response to illness. Has anybody ever tried or benefitted from inducing fever artificially by drugs or by heat applications?
 

pamojja

Senior Member
Messages
2,298
Likes
3,352
Location
Austria
Has anybody ever tried or benefitted from inducing fever artificially by drugs or by heat applications?
I too heard hyperthermia is used in some German clinics to assist immunity in cancer patients.

Would this be very different from taking a hot bath
Except for not controlled temperatures, also sauna-use could heat the body-core temperature up.

Personal anecdote: didn't get any fevers for many decades too. In 2012 had a chronic bronchitis for a whole year, whiich in the end I tried to get rid of with sea-air at a South-Indian beach. However, did get an UTI, which after some time proceeded to a month long of high fevers, sweats, vomiting and diarhea (suspect thypoid fever). After that long month my bronchitis was gone with the fevers.
 

gbells

Improved ME from 2 to 6
Messages
1,433
Likes
1,786
Location
Eastern NC USA
In my opinion a fever won't help you because it won't clear chronic viral infections and there will be a big energy drain from the increased metabolism. ME patients appear to have lower body temperature and fevers as part of mitochrondral fragmentation to slow viral spread.
 

Judee

Senior Member
Messages
2,788
Likes
7,924
Location
Great Lakes
There was a guy online who had modified Wilson's Temperature protocol and believed you could do what you are saying but I cannot find his website now unfortunately.

I did try it for a while but it was difficult being so bundled up all the time. I normally wear 2-4 layers of clothes now as it is.
 

gbells

Improved ME from 2 to 6
Messages
1,433
Likes
1,786
Location
Eastern NC USA
why don't you think? isn't that what fever is supposed to do?
Because chronic viruses integrate into the cell's DNA and become widespread and resistant to apoptosis. It isn't an effective way to kill them. It only works to slow viruses down during the acute stage of infection before they get entrenched. See posts in the Immunotherapy group for more info. After they are established it becomes self defeating.
 

Judee

Senior Member
Messages
2,788
Likes
7,924
Location
Great Lakes
@gbells, would it help to clear bacterial infections though like Lyme?

I remember reading of one Lyme patient who went to Germany to have a treatment where they heated her blood for several hours to kill the Lyme.

If bacterial infections got cleared wouldn't it help the body to get rid of the others??
 

gbells

Improved ME from 2 to 6
Messages
1,433
Likes
1,786
Location
Eastern NC USA
@gbells, would it help to clear bacterial infections though like Lyme?
That's an interesting question. My understanding is that bacterial infections (lyme, rickettsia etc) clear up with a few weeks (2-6) weeks of appropriate antibiotic therapy so there is no need for it.

Perhaps the problem is that MDs are having problems identifying the bacteria and don't want to give antibiotics without lab confirmation. We know that HHV-6 masks EBV antibodies so perhaps something similar could be causing false negatives or there is just a new bacterial species. I had that problem with a nonspecific rocky mountain spotted fever positive result and literally had to twist the infectious disease doctor's arm to get a course of doxycycline. It eliminated chronic headaches I had for years after a flea bite from a feral cat. They never were able to identify the pathogen despite PCR testing for everything.

If you have some articles on blood heating as a treatment please share.
 
Last edited:

JES

Senior Member
Messages
1,187
Likes
2,805
I have been curious about this ever since I found out my symptoms resolved during colds. There is a fever effect that has been documented in autism and some other diseases, where getting a fever temporarily improves symptoms, which you can read about e.g. here. I assume the proposed effect of fever therapy is that it would knock down any infections that a real fever would.

The problem, as the linked article pointed out, is that just raising the temperature in mice did not have any effect on their behavior. Rather it's the infection itself triggering changes in the immune system and production of certain cytokines that apparently reduce the symptoms. This ties into what Ron Davis has observed in some of his patients. After having caught an infection, many of their symptoms and some of their blood parameters improved shortly afterwards.

So to answer the original question, I think raising temperature isn't enough to replicate things happening during a real fever and therefore wouldn't be of much use.
 

MartinK

Senior Member
Messages
319
Likes
492
Artificially induced fever interested me!
I got only 2x low fever during my CFS, but each time it caused something similar to a short-term improvement in all symptoms.
I'd like to try it artificially, true ;-)
 

gbells

Improved ME from 2 to 6
Messages
1,433
Likes
1,786
Location
Eastern NC USA
After having caught an infection, many of their symptoms and some of their blood parameters improved shortly afterwards.
Perhaps its due to immune exhaustion. Could be the same reason ME patients did better with Rituximab. Immune response is a big energy drain. If you sabotague it the energy is freed up so the person feels better.
 

JollyRoger

Senior Member
Messages
129
Likes
127
I had this therapy. They used bacterial toxins to induce the fever (Great Th1 Booster).
You get the fever usually 1-2 hours after the injection.
My fever started four hours after the injection.
My blood oxygen dropped to 93%.
Both things never happened in their clinic (even not in all the cancer cases) because I was the first case with CFS there.

After the forth time I stopped because I felt no change.
 

Judee

Senior Member
Messages
2,788
Likes
7,924
Location
Great Lakes