anyone with cfs tried ivermectin?

dylemmaz

dylemmaz

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my cfs specialist really wants me to try ivermectin. i have the script but i’m a bit nervous about using it. she wants me to do a 2 day on 5 day off protocol, body weight doses the 2 days that i take it. and then repeat this cycle for 3-4 weeks.

she said she has seen success treating long covid patients with it. i don’t have long covid though, i’ve had cfs for 4 years. she suspects it will help primarily with nueroinflammation, which i’m certainly suffering from.

anyone able to curb my concerns? have you tried ivermectin for your cfs? did it help?
 
Rufous McKinney

Rufous McKinney

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Rufous McKinney said:
he likely would say the following: Avoid that, too.
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I haven't researched it....much.

The blood sugar pill medicine currently Drs. love was basically was derived from bitter gourd, a plant used in chinese medicine.

My practioner says: I should never take that- its the WRONG route in my type of body.

So I'd go via some other route.

Which makes me wonder if the Ivermectin result: can be achieved via some other route.

With a pharma copia of 6000 herbs used over 2000 years, they have alot to work with.
 
Rufous McKinney

Rufous McKinney

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dylemmaz said:
my cfs specialist really wants me to try ivermectin.
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The attached describes how Ivermectin was developed in Japan and this entire thing is pretty fascinating.

A "Wonder Drug".... it came from soil bacteria, collected near a golf course in the 1970s.

https://www.isglobal.org/en/healthi...el-suelo-a-las-lombrices-y-mas-alla/3098670/0

they modified in the lab chemically- to be a bit different from the naturally derived compound.

I intend to: figure out more about how this was changed chemically and: whether there are equivalents in the CTM protocols.
 
dylemmaz

dylemmaz

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nerd said:
I use it. 0.2mg/kg 1-2 times weekly. It's a very safe drug. One just shouldn't take alcohol or recreational drugs at the same time, which ME patients probably won't do anyway.
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what has it helped you with? you seem well informed, are the neurotoxicity risks quite low?
 
dylemmaz

dylemmaz

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andyguitar said:
As you say, you dont have long covid. Sounds like a shot in the dark, this idea that long covid and cfs are the same so should be treated the same way.
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i know, i certainly remain skeptical. i’ve very rarely heard of it being used in cfs so that’s why i was originally concerned. i’d prefer not to be a lab rat, unless the drug has very little risk.
 
Martin aka paused||M.E.

Martin aka paused||M.E.

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dylemmaz said:
my cfs specialist really wants me to try ivermectin. i have the script but i’m a bit nervous about using it. she wants me to do a 2 day on 5 day off protocol, body weight doses the 2 days that i take it. and then repeat this cycle for 3-4 weeks.

she said she has seen success treating long covid patients with it. i don’t have long covid though, i’ve had cfs for 4 years. she suspects it will help primarily with nueroinflammation, which i’m certainly suffering from.

anyone able to curb my concerns? have you tried ivermectin for your cfs? did it help?
Click to expand...
Isn't there a new study from Latin America which showed no effect in Long Covid? Also here in Germany it's quite expensive
 
nerd

nerd

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dylemmaz said:
what has it helped you with? you seem well informed, are the neurotoxicity risks quite low?
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Difficult to tell. The neurotoxicity risks are negligible. You have greater risks from drinking alcohol. Dysfunctional MDR-1 genes aren't common. People with mutations in this gene would have an issue with taking medications anyway eventually, because many medications rely on this gene. If you start with a lower dose and increase the dose day by day, you can monitor if any side effects occur. If you feel dizzy or sleepy like you're drunk. That will be your limit. The drug itself isn't neurotoxic. It's just the dosage in the brain that can make it neurotoxic. Just like drinking ethanol. But ethanol always crosses the blood-brain barrier easily, Ivermectin only in very low concentrations.
 
nerd

nerd

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bread. said:
Does it help?
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Difficult to tell. I've changed many things. The only thing that clearly put me into partial remission was the keto diet, but only for a certain period of time. It seems to have disappeared along with my keto rash. But I'm still in ketogenesis. I have the impression that I don't experience cold symptoms anymore during PEM. This could be due to many things, but Ivermectin is the first-best explanation. I also expect some antiviral effects from it, but virostatics and viromodulators need a long time to work against latent and abortive infections to make any difference.

Ivermectin isn't a functional fix to the CFS/ME pathophysiology. I also checked if it is an HDAC modulator due to its GABAergic modulation and its ionophore property, but it's too large to attach to the HDAC enzymes' zinc site. It's a tick too large to classify as a small molecule. Regardless, it still induces apoptosis and autophagy selectively via the mechanisms that viruses like EBV modulate to evade the innate immune system (e.g. via Bcl-2 and mTOR modulation). This makes it a multi-functional helper tool in antiviral treatment. On its own, however, it is only useful against parasites and SARS-CoV-2. To eliminate other viruses from the system, it needs combination treatment. I still work on this.
 
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Marylib

Marylib

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I'd try it if I could. Why not? I'm surprised no one has thought of it before. Look at the suranim trial that came to a halt because of a drug patent issue. Look at all those people who survive on antivirals for this disease, until the kidneys give out. It's current application seems to be in those newly diagnosed, which means Long Covid. Bruce Patterson seems to already have a patent (or working on one) for a diagnostic test for Long Covid (complicated immunology discussed in a video I posted elsewhere.) His clinic is using ivermectin, as well as the usual supplements, mast cell stablizers, modulating neurotransmitters, steroids if it's really bad, etc. The thing that sticks out to me in the protocol below is statins. The protocol is no secret, and certainly no more out of left field than low dose aripiprazole or the fasting regimen that used to be on this forum. Precision medicine is what everyone hopes for.
https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/

"Ivermectin is a versatile drug with unique characteristics, which make it interesting also for basic and applied research (in particular for drug repurposing): it seems to reveal an antibacterial (Lim et al. 2013; Ashraf et al. 2018), antiviral, and anticancer activity (Juarez et al. 2018; Intuyod et al. 2019), besides being potentially useful for the treatment of some chronic pathologies (Ashraf and Prichard 2016; Ventre et al. 2017), result of an action on a wide range of cellular targets."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251046/
 
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Marylib

Marylib

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GeorgiaLinders

GeorgiaLinders

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from what i've seen, Ivermectin is being used along with a few other meds. these doctors think their way of approaching Long Covid can be used to treat ME/CFS.

 
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