Anyone used those bloodsuger control medications?

[Hufsamor]

By the way, I didn't mean it as a criticism that the authors had only tried the medications on serum. Obviously that is a good and cautious way to start. Apologies if it came across as a negative.

I didn’t read it as negative at all
Only like a question. And an important one as well.

 

[wabi-sabi]

Apologies if it came across as a negative.

Oh, not at all.

 

[Oliver3]

Uncontrolled diabetes can cause nerve damage in many parts of the body including the GI tract. But lots of other things can cause nerve damage too. Gastroparesis in pwME does not necessarily mean that there are sugar issues, due to the nervous system problems caused by ME/CFS. Gastroparesis is part of the dysautonomia picture, like the problems with heartrate and blood pressure

All I know experience wise is berberine has stabilised me very markedly and I'm still feeling it's benefits 3 months after starting which is not my normal experience with drugs or supplements. I feel oxygenated far more abd have endurance. It's not a cure.
Korean ginseng, low dose aspirin, beta blockers, amlodipine, ramipril, brocoli sprout seeds, lots of water abd now adding berberine has improved me a good bit..I was very sick. I still am but it's doable. Adding berberine into that mic was so noticeable

 

[wabi-sabi]

All I know experience wise is berberine has stabilised me very markedly and I'm still feeling it's benefits 3 months after starting which is not my normal experience with drugs or supplements.

Berberine may also be beneficial for blood sugar control in diabetes. However, it does not work in the same way that saxagliptin does to help control sugar.

Berberine has a whole smorgasbord of functions, listed in the paper below. You might be feeling better due to one of them, or if you are diabetic or insulin resistant you might feel better because berberine is helping with that.

In this paper, berberine has some effect on blood vessels and helping to keep them healthy and reduce inflammation. Since malfunctioning blood vessels are one of the problems in ME/CFS, perhaps that's why you feel better. More oxygen to the tissues is a good thing. Of course, this is just a guess on my part.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8964367/

 

[Oliver3]

The difference when adding berberine to my regimen was day n night. I don't have diabetes..I suspect there's more than one action at play. Like you say , supporting endothelium, perhaps immunity modulators factors we don't know about, perhaps the inflammatory process involved in m.e. abd I'm still thinking there's anthg about how sugars work in the brain.
If I add chromium into that, I can think so clearly. I'm just loathe to do so because of the effect on the kidneys.
Smthg with blood sugars in the brain is part of this.
My sister has pcos but not diabetes yet. Pcos runs in the family and I think glucose in the brain is effected somehow.
We saw in that first ' blood test for m.e.' that there were insulin resistance and elevated liver enzymes. I suspect berberine is helping here too.
It seems to be a really good medicine which doesbt have fhe side effects of metformin.
I think the jury is out on what's going on with fluge and mellas work. But uts encouraging.
There us definitely a problem with insulin resistance in most patients, seems to be a universM finding.
I can only say that berberine has taken ne out of a very orecariousspot.
I think there needs to be more work on the likely plethora of modes of action at play

 

[Oliver3]

That's a pretty comprehensive paper on berberand it is very encouraging and corresponds with my experience.
Improving vascularity, neuro protective etc etc.
If anyone can tolerate it it I'd suggest getting some clean berberine on a trial basis.
Thanks for the post

 

[wabi-sabi]

We saw in that first ' blood test for m.e.' that there were insulin resistance and elevated liver enzymes.

This is a very good channel for explaining and helping with insulin resistance if you want some dietary changes:

There us definitely a problem with insulin resistance in most patients, seems to be a universM finding.

I've never been insulin resistant in my whole life. I know there was a recent paper done on UK Biobank data showing this in many patients, but I remain unconvinced whether it's part of ME or not. Insulin resistance is so common in the general population... but my sugars and lipids have always been normal, with or without ME. And there was an earlier paper on metabolic types in ME... there were three types and only one had insulin resistance. But, if you can get your insulin resistance under control, go for it! Your health will be much better for it.

You know, it's part of the whole "All your labs are normal, so therefore you have depression", that so many people experience. No insulin resistance, no bad liver enzymes, no high cholesterol for me. I guess it really is all in my head.

 

[Oliver3]

This is a very good channel for explaining and helping with insulin resistance if you want some dietary changes:

I've never been insulin resistant in my whole life. I know there was a recent paper done on UK Biobank data showing this in many patients, but I remain unconvinced whether it's part of ME or not. Insulin resistance is so common in the general population... but my sugars and lipids have always been normal, with or without ME. And there was an earlier paper on metabolic types in ME... there were three types and only one had insulin resistance. But, if you can get your insulin resistance under control, go for it! Your health will be much better for it.

You know, it's part of the whole "All your labs are normal, so therefore you have depression", that so many people experience. No insulin resistance, no bad liver enzymes, no high cholesterol for me. I guess it really is all in my head.

These neds probably have many other mechanisms of action.
Angioprotective being one