Anyone Tried Pramipexole (Mirapex)

[Jackb23]

If Stanford is pushing Abilify, isnt there reason to believe that Mirapex might work too with different side-effects?

I know it is kind of the holy grail for anhedonia in depression. Its also way more selective.

 

[Judee]

Someone was talking about it in this thread: https://forums.phoenixrising.me/thr...please-explain-this.80654/page-3#post-2297622 (pages 3 and 4)

Not sure if the whole thread is about that though.

 

[hmnr asg]

We were also discussing Pramipexole (Mirapex) in one of the threads about abilify:
https://forums.phoenixrising.me/threads/abilify-stanford-clinic-patients.62807/post-2436256

I am very curious to know how it affects cfs. So if anyone has tried it please let us know!

 

[Springbok1988]

I tried pramipexole but didn’t get much benefit. My mood would swing from a little better than normal to very irritable. I didn’t get an improvement in fatigue. Same thing with ropinerole.
I tried abilify and felt an improvement for a few days but then I crashed with PEM and it stopped working.

 

[Hip]

About a decade ago, I had low motivation, and found low doses of pramipexole (½ of a 0.18 mg tablet daily) worked well to treat this. It also boosted mood.


Also I noticed that vitamin B2 50 mg, taken two or three times daily, for some reason would significantly boost motivation.

Pramipexole did not however do much for my anhedonia.


Some years later, however, when I tried pramipexole once again, I found it had different effects, and actually no longer gave me a mood boost, but instead caused emotional weakening and reduced my sociability.

This might be due to changes in my brain that occurred during the intervening years.

 

[Judee]

Also I noticed that vitamin B2 50 mg, taken two or three times daily, for some reason would significantly boost motivation.

Does this still work for you?

 

[Hip]

Does this still work for you?

I don't have lack of motivation now, so I can't tell if it still works. But I decade ago, I had pathological lack of motivation.

I remember once that I spilt some coffee from my mug onto my desk. It was a small spill that needed to be moped up with a piece of tissue paper or kitchen cloth. But my brain would not engage into the this small task. I just kept staring at the coffee spill, knowing it needed to be cleaned, but I could not coax my brain into initiating the task.

I had similar issues with lots of small tasks, that needed to be done, but the brain did not engage.

It's this task initiation that is missing when you have low motivation.