When I started oxymatrine on Oct 8, 2019, I tried to make my own version of Equilibrant so that initially I was getting a very tiny amount of the oxymatrine--maybe like 1/6th of a pill a day. I increased it weekly until over the course of a month or two I was finally taking the equivalent of 1 oxymatrine. Mixing and doing the math was a pain so at that point I just switched to the whole oxymatrine pill.
Then I gradually increased it again over about a 6-month period until I got up to 3 pills of the Alternative Medicine Solutions variety. I had some times when sleep would actually seem somewhat refreshing. That gave me some hope to keep going with it.
A few months ago, I went back down to two a day, but when
@JohnnyMinnesota99 mentioned
here he was crashing after he reduced his dose, I decided to go back up to 3 again and got that refreshing sleep feeling again so I think that means I need it. (
@EddieB, I see you already saw that thread.)
It hasn't cured my ME/CFS because I think I have some bacterial things are going on as well but it is one of the supplements (along with 400mcgs of selenium that
@Hip recommended) that gets me out of that danger zone where I feel like I am just going to pass out at any moment.
Also I find that the Alternative Medicine Solutions form seems to work the best. I have also used Nature's Health Ku Shen as well as Tiger Brand. Tiger Brand is actually the cheapest when I purchase it through
this place. They even send out $5 off an order of $50 coupon codes sometimes.
However, as I said I like the AMS version the best. It is when I am on it that I get that refreshing sleep feeling the most often.
I may also try going up to a higher dose for a few days at some point to see if I get more benefit however the bottle recommends just 3 per day for a max dose of 900mg.
Some of this I am going by memory which as you know

but I do not remember horrible side effects by starting low and increasing it so slowly. I may have herx'd a little but I don't remember.
I do have auto-immune in my family but was desperate and so far after taking it this long daily, I have not developed RA, at least not that I am aware of and I think for something like that, I would probably be experiencing some of the symptoms by now.