I have high liver enzymes too yes, and I also have mast cell activation syndrome. However I suspect the MCAS isn't the direct cause in my case, rather whatever the underlying problem is it's causing them both. I suspect mine is bacterial dysbiosis which release endotoxins and also trigger mast cells.
I wonder how many of us have frequently elevated ALT and AST and if its a higher percent than in the normal population, or perhaps populatin with chronic illness.
Probably we all have different reasons for liver enzyme elevations. I think i had mast cell activation issues since infancy, inference based on food reactions and dermatographia at age 10 (and a genetic finding). So for me , that came first. In your case sounds like mast cell overreaction came later. In me, i still don't know if mast cells have caused my elevated liver enzymes I just know the standard battery of livre tests has never turned up anything. And kmow that any new viral illness raises my liver enzymes. I have figured my chronic ellevations are related to oxidiative stress and in my case have assumed it was the extnesive dental work that put me in the land of the sick (at least wave 1. So for me related to detox of the dental chemicals. But recently was reading that mast cells can "infilitrate the liver" whatever that means and elevated liver enzymes can be up in MCAS (though also said for many its cholosteroal related and alk phosphatase- not relevent for me usually) , so it has added a new hyopothesis to explore. Hence wanting to know how many have both mcas and liver enzymes though i suppose a more basice question is yeat another poll- how many have had chornic elevations in ALT and AST with some definition of chronic provided. But since only 37was the max poll responses i've ever gotten, doesn't seem worht the effort.
One step is seeing how many with CFS have both liver enzyme elevations along with a mast cell problem. if that turns out higher than those with cfs that have elevated liver enzymes but NOT a mast cell problem, then one can start to pull apart possible reasons for the association between the enzymes and the mcas.