Protandim worked for me
I was doing research on Protandim and this thread came up. I can't say what would happen for everyone, but I had a great improvement in CFS symptoms using it. I have done a lot of work trying to restore my health with MDs, Naturopathic and Chinese doctors, homeopathy, an Ayurvedic spa, you name it. I had improved somewhat, but couldn't seem to get any farther (I'm 56 and had stage 3 ovarian cancer when I was 25, I believe I had high levels of pesticide exposure as well as heavy metals from art materials, as I aged, more health issues came up and my immune system dived).
Maybe I should just mention that Protandim is a combination of 5 Ayurvedic and Chinese herbs that have an unusually powerful synergistic effect. Protandim greatly reduces both oxidative stress and inflammation.
Initially, I felt a boost for a couple days, then I had about a month of some detoxification symptoms-some headaches, lower energy, aches, etc. This was annoying but not severe. After that, I started to feel more energy and various issues like joint inflammation were clearing up. It's 6 months later and I can honestly say that I feel really good for the first time in 7 years, and am far more productive than I have been in a long time. Many of my friends are also taking it and have had improvement with many varied conditions, from restless legs to asthma. I don't have enough basis for comparison on CFS to say what it does for everyone, but I think it is well worth trying.
I would recommend at least 3 months of trial to see what it does. I hear that most people don't experience detox symptoms. If you do, you could back the dose down a bit until it subsides, then go back to a full capsule. The usual dose is one a day. I do take 2 sometimes when I am under greater stress. It is best to take it with food, earlier in the day. A little fat content in the food is supposed to help some of the herbs absorb better.
I think that oxidative stress and inflammation were both big for me. Studies on Protandim show it reduces oxidative stress (free radical damage) by 40% in the first month and up to 70% in 4 months. They don't talk about inflammation as much but it is listed in all three of their patents. I no longer take massive doses of fish oil and other herbals for inflammation control, this has handled it. More information is available at
http://www.antidotetoaging.com You could go to
http://www.pubmed.gov and search Protandim to see the published studies they have on it so far, 7 in number, but many more are in process.
It takes a little study to wrap your head around what this supplement does, it is not the same as other antioxidants. It actually stimulates the genes to produce your body's own antioxidant enzymes through the Nrf2 pathway. It results in your body producing much higher levels of SOD, catalase, glutathione and other powerful enzymes. I'm guessing from my study on glutathione that it may be what really helped me. It helps the body detoxify and greatly supports the nervous system and brain. My mom had Parkinson's and that goes along with low glutathione levels. They know that Protandim raises glutathione by 300%.
Another good sign is that I have not been sick since I started on it, no colds, sore throats, etc. I did hit the echinacea here and there if I thought I felt anything trying to get into my respiratory tract, but I was able to fight it off.
In the end, I'm just happy to feel better, and I am now focused on sharing it.