I do know from my countless trials and research that pathways can be tricky, but ultimately, there is a missing co-factor being a specific vitamin, then I look for mineral balance and then other aminos. The link I shared discusses some common vitamins that are involved.
Quote Reply
Yesterday at 3:35 AM
Report Edit
V
vision blue
Senior Member
Messages642Likes814
Hi. Thanks for sharing your literature search. My perspective was different.
O e of the pieces was “- Mildly elevated serine can be a sign of vitamin B6 insufficiency or pyridoxal 5-phosphate coenzyme dysfunction.
- High levels of serine when accompanied by
low threonine, indicates glucogenic compensation and catabolism.
Supplement threonine and BCAAs”
And “Serine can be used as an energy source. Formed from
threonineand
phosphoserine (requiring B6, manganese, and magnesium), serine is necessary for the biosynthesis of acetylcholine, a neurotransmitter used in memory function.”
Need to see if I can find the original message that I posted on the list in my notes on it all before I ended up deleting it.
My recollection is reading with there were a couple of different ways in which serine could be elevated, and one was bby way of the Serine Synthesis Pathway (SSP).
I Was able to determine from my other amino acids that this appeared to be the Source of my elevation. Further reading then suggested that this was a bad thing Since it is only used in drastic circumstances pretty much. So either desperate need for energy or is used by cancer cells to grow. Then I also remember concluding that it’s possible I was prediabetic but that could be a cause to but I no longer remember why I came to this conclusion. I will try to find my notes on it
Unlike Quote Reply
Yesterday at 4:43 PM
Report
Likes:
You
[IMG]https://forums.phoenixrising.me/data/avatars/m/27/27834.jpg?1484210111[/IMG]
LINE
Senior Member
Messages367Likes751Location
USA
Thanks for that information. I do not know where you are with this CFS process but I can say that there are many endocrine/immune/neuro shifts that occur.
Obviously with immune activation, there are profound changes that occur since the immune system is the strongest force in the body. It requests the endocrine system to help fight the primary problem and with these endocrine shifts then cell function is altered.
Alteration of cells then begins to morph the responses of the body. One part of the endocrine responses includes adrenal function which turns on to support the immune response. The adrenals produce many hormones that change cell behavior but also use nutrients at high levels.
One nutrient that comes to mind is magnesium, I pick up on this with your statement of "pre diabetic" since magnesium is a good possibility. Of course, there could be many other possibilities. I wonder if you had any mineral testing done.
Quote Reply
Yesterday at 6:36 PM
Report Edit
V
vision blue
Senior Member
Messages642Likes814
HI. I found my original post to the group on serine. I've pasted back into the thread and very curious to know if you have any comments and if that meshes with what you've unconvered or if you've just been wokring on serine things unrelated to these issues.
in answer to your question here, Depends which minerals? I was able to identify a magnesium deficiency based on amino acid test results and blood test was also right at the cutoff of normal, which of course means we know its likely not in the cells. but that was several years ago. As you'll see in the post, i was able to fix that though have back slid a bit. Based on all things considered, a magnesium defieiceny does not seem to be the casue of my increase in urinary serine. And if anythign, as you'll see in the post, since magesium is needed to covert phosphserine into serine , if anything, repleting magnesium is what allowed the serine increase to manifest.
Maybe if we discuss stuff on the thread, others will chime in? Not sure. alot of people probably don't realize how important this all is to CFS because of its role in glycolosis which is all screwed up along with krebs in CFS.
Like Quote Reply
Today at 10:35 AM
Report