Anxiety in ME-patients (BECAUSE of the ME, not the other way around.)


Senior Member
Approximately 80% of serotonin receptors are located in the gut -- so sometimes anxiety in CFS/ME may be related to intestinal dysbiosis or fungal/candida infections and can be improved by treating the infections or supplementing with different high-dose probiotics.

But yes, different forms of anxiety are definitely a part of CFS/ME.
I can definitely attest to the theory that sometimes anxiety in CFS/ME is related to intestinal dysbiosis. There are several gut-brain connection paths (vagus nerve link, nitric oxide signaling, cytokines), and it turns out that gut infection and inflammation can have a knock-on effect, and kick off brain inflammation (Ref). Brain inflammation has powerful and deleterious effect on mood, and can give rise to anxiety and depression symptoms.

Once I started taking generous doses of PREBIOTICS (rather than probiotics) to fix my gut dysbiosis, within a week or so, my anxiety symptoms were vastly improved.

Some info on the use of PREBIOTICS to soothe gut dysbiosis/inflammation is here: The Wonders of Prebiotics. If you are going to try this prebiotic protocol, please use high doses of more than one type of prebiotic, two or three times a day. This makes all the difference. Probiotics may be useful too, but I thing they are not as important as prebiotics. At least, that is what I discovered.

I hope this prebiotics protocol helps others fix their anxiety/depression as much as it helped fix my mental miseries.