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Antipurinergic therapy for mito dysfunction and chronic inflammation


Senior Member
Robert Naviaux, of that fab Cell Danger Response paper (there is a thread on it somewhere) is the first speaker in this recent conf panel.

The Cell Danger Response (CDR) is defined in terms of an ancient metabolic response to threat.

The CDR encompasses inflammation, innate immunity, oxidative stress, and the ER stress response

The CDR is maintained by extracellular nucleotide (purinergic) signaling.

Abnormal persistence of the CDR lies at the heart of many chronic diseases.

Antipurinergic therapy (APT) has proven effective in many chronic disorders in animal models.


Senior Member
Has there been any research to show elevated extracellular ATP in Autism or other neuroimmune disorders I wonder?