Anti-amphiphysin

[cfsfaithhopelove]

My loved one had a positive anti-amphiphysin test but they doesn’t appear to have stiff-person syndrome? They do have autism.
Any suggestions of why it’s very elevated?

God bless!

 

[SWAlexander]

Any suggestions of why it’s very elevated?

While there are many variations to amphiphysin, there are quite some papers available, I suggest reading this first:
Human autoantibodies to amphiphysin induce defective presynaptic vesicle dynamics and composition
https://academic.oup.com/brain/article/139/2/365/1753708