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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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The Kennedy group found no elevation of ET-1 in CFS:
Still thinking that ANP plays a major role in ME/CFS's volume depletion. Prostaglandins (PGF2 alpha, PGE2) and oxidative stress (MAPK p38, PKC) can increase ANP without increasing ET-1.
Maybe this means that they were relatively well-rested. Perhaps levels would be different after exertion?ET-1 levels were measured from a morning blood sample.