Amenamevir: Novel antiviral against herpes virus family approved in Japan

Wonkmonk

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"The product is an anti-herpes virus agent with a novel mechanism of action created by Astellas Pharma Inc. (“Astellas”; Head Office: Tokyo, President and CEO: Yoshihiko Hatanaka). The product has been observed to inhibit the proliferation of the varicella-zoster virus (hereinafter VZV) by inhibiting the activity of the helicase-primase complex, which is essential for viral DNA replication. […]The product is proven to be effective against VZV when administered once a day after meals. […] General administration for adults is 400mg of amenamevir once a day administered orally after a meal"

https://www.maruho.co.jp/english/release/nek5p40000001vpv-att/20170703_pr_eng.pdf
 

Hip

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Looks like www.mimaki-family-japan.com sell amenamevir (Amenalief), but it is not cheap at $720 for 14 x 200 mg tablets.

By the way, I was not able to load the website of Mimaki Japanese Family pharmacy from the UK, nor from the Netherlands via VPN (it is temporarily blocked in the EU due to GDPR issues, although it does ship to the EU).

But was able to load the site when using a VPN in the US and Canada.
 
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Wonkmonk

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So that's probably meant to be a 7-day course for treating shingles. Costs for long-term use at the recommended dose would be way too high for most people.

Maybe the exchange rate makes it more expensive and it gets more affordable when a local version is available, but it's still going to be very expensive.

I am wondering if amenamevir could block herpes virus replication in early replication stages. Dr Lerner pointed out that, as he thinks incomplete early herpes virus gene products cause CFS in some patients, that if his theory is correct, patients could improve much more quickly and comprehensively with a drug that stops early replication steps. Valacyclovir and famciclovir only stop late replication steps and therefore, according to Dr Lerner, are only limited in their effectiveness.

So maybe amenamevir could be used to test his theory.
 

Wonkmonk

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I am wondering if amenamevir could block herpes virus replication in early replication stages.
If I am understanding this correctly, this is in fact what amenamevir does (emphasis added):

"Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands."

https://www.ncbi.nlm.nih.gov/pubmed/29451274
 

Hip

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When ME/CFS in linked to active varicella-zoster virus (VZV) infection (which may produce shingles blisters, even just one or two blisters), Dr John Chia finds that patients can dramatically improve within weeks on acyclovir. See timecode 6:58 in this video interview with Dr Chia.

So when ME/CFS is due to VZV, acyclovir (or Valtrex) treatment may be all you need.
 

Wonkmonk

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FYI: My local pharmacy says they can order Amenamevir 200mg, 14 tablets, directly from the manufacturer at a cost of ~350€.

If anyone is interested, I can provide contact details. They should accept EU prescriptions and be ready to ship abroad for a fee, but I'm not entirely sure about that.

Anyway, if my pharmacy can get it, I'd assume others in the EU can, too.