If you are a night owl, a supplement containing a cortisol-regulating nutrient called phosphorylated serine (brand name Seriphos, this is not the more readily available phosphotidyl serine), taken before dinner (approximately four-six hours before bedtime), should get you to sleep.
If you wake up between 2:00 and 4:00AM take Seriphos at bedtime (by 10:00PM), 4-6 hours before you would typically wake up in the early morning. If you have trouble getting to sleep and you wake up between 2:00 and 4:00AM, take one capsule before dinner and two by 10:00PM. Seriphos encourages your pituitary gland to stop sending the order to your adrenals for more cortisol production. After a month or so, this normalized message should be permanently re-programmed, and you should not need any more Seriphos. Caution: Do not take Seriphos for more than three months total. Take a break for at least 24 hours after each month’s use (as per bottle directions).
A second possible solution: A quicker-acting supplement called hydrolyzed casein or lactium (e.g., De-Stress by Biotics) has calming effects on the brain. It was originally researched in France. Take 75-150 mg. whenever your cortisol is elevated, day or night. It seems to work best if you are also taking Seriphos. Do not take it if you are milk intolerant. Holy Basil can also help.
Remedies for daytime mood disturbances caused by elevated cortisol: The same two supplements may be used to lower daytime cortisol levels. Take Seriphos (1-3) hours before your test shows abnormally high cortisol elevation. Or try lactium when your test shows that a cortisol elevation is occurring (you actually feel more agitated then).
Retest your middle-of-the-night, early morning, and/or bedtime cortisol again (whichever was abnormally elevated) in three months to see if your levels have dropped to normal.
From:
https://www.juliarosscures.com/identifying-and-correcting-elevated-cortisol-levels/