AIM ImmunoTech Announces Update on Ampligen Long Covid Development Program

[Treeman]

AIM ImmunoTech Announces Update on Ampligen Long Covid Development Program - Solve ME/CFS Initiative (solvecfs.org)

A Phase 3 prospective, double-blind, randomized, placebo-controlled trial of Ampligen in ME/CFS (AMP-516) produced improvement in exercise tolerance. An analysis of a subset of patients in that trial with early onset of symptoms showed a statistically significant 51.2% positive response

(301) Ampligen: A General Overview and the Plan for ME/CFS & Long Covid - YouTube


I may be late to the game, so apologies if this has already been shared.

 

[mitoMAN]

Nice it might finally hit the market in 2050 and sold off label for a fortune to us

 

[hapl808]

Nice it might finally hit the market in 2050 and sold off label for a fortune to us

!remindme 2050.

 

[heapsreal]

Nice it might finally hit the market in 2050 and sold off label for a fortune to us

Yes, I will be 6ft under by then 🤣🤣

 

[SlamDancin]

Is there nothing else in the FDA catalogue or amongst natural products that works like Ampligen? I believe it’s a TLR3 agonist.

 

[mitoMAN]

Is there nothing else in the FDA catalogue or amongst natural products that works like Ampligen? I believe it’s a TLR3 agonist.

Sadly not. Poly:IC is toxic

 

[heapsreal]

Is there nothing else in the FDA catalogue or amongst natural products that works like Ampligen? I believe it’s a TLR3 agonist.

There are different immunotherapies used for other conditions, I'm sure there's ways to increase nk function.
Was a research Dr in Australia who treated MS by extracting the pts T cells and hyping them up somehow to fight ebv and then reinfuse the T cells. I recall he was experimenting on only 1 pt at the time and put them into remission. There is a few posts on here about this Australian researcher.
I think treatments like above are possible but getting them approved and cost etc would be too much. Maybe getting a drug indicated for one specific abnormality might be easier like low nk function or T cell function but for just a diagnosis of cfsme, I'm not sure much at all will be specifically prescribed because cfs isn't really well diagnosed or abnormalities aren't recognised like low nk function, which has even known for over 30yrs.

 

[Redtruck99]

There are different immunotherapies used for other conditions, I'm sure there's ways to increase nk function.
Was a research Dr in Australia who treated MS by extracting the pts T cells and hyping them up somehow to fight ebv and then reinfuse the T cells. I recall he was experimenting on only 1 pt at the time and put them into remission. There is a few posts on here about this Australian researcher.
I think treatments like above are possible but getting them approved and cost etc would be too much. Maybe getting a drug indicated for one specific abnormality might be easier like low nk function or T cell function but for just a diagnosis of cfsme, I'm not sure much at all will be specifically prescribed because cfs isn't really well diagnosed or abnormalities aren't recognised like low nk function, which has even known for over 30yrs.

That was Dr. Michael Pender. The ATA188 T cell treatment for EBV in MS was picked up by Atara Biosciences and is now in phase 2 trial, with plans to start phase 3 announced. Patients in the trial re reporting good results. Published results look good. Here's a profile on it https://bit.ly/3mIHYmz

I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

There's much overlap between MS, ME/CFS, and Long Covid, in particular, latent and reactivating viruses, especially EBV, but many other viruses may be contributing to the pathology.

 

[mitoMAN]

That was Dr. Michael Pender. The ATA188 T cell treatment for EBV in MS was picked up by Atara Biosciences and is now in phase 2 trial, with plans to start phase 3 announced. Patients in the trial re reporting good results. Published results look good. Here's a profile on it https://bit.ly/3mIHYmz

I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

There's much overlap between MS, ME/CFS, and Long Covid, in particular, latent and reactivating viruses, especially EBV, but many other viruses may be contributing to the pathology.

sadly I expect ATA-188 to cost well over 100k$ off label for ME/CFS

 

[Redtruck99]

sadly I expect ATA-188 to cost well over 100k$ off label for ME/CFS

I know, it is so unfair. But what is the status on EBV as a cause of ME/CFS? I remember the rituxamab trial didn't work out.

 

[Redtruck99]

If Ampligen has completed Phase 3, it should only take 1-2 years to file for BLA and enter Phase 4, when it can be prescribed for ME/CFS. Here is the latest news I could find on this - good news if you live in Argentina!
And "we continue to seek regulatory approval for commercial sales to treat ME/CFS patients in the United States."

Jun 15, 2020
AIM ImmunoTech Provides Update on Commercial Launch of Ampligen(R) in Argentina for the Treatment of Chronic Fatigue Syndrome

 

[mitoMAN]

In Argentinia its approved but not on the market and not covered by insurance (my relative lives there)
Sadly. That was the status of mid 2021 I believe.

I doubt anyone there could afford it anyways haha. The clinical trial charged 1000$ per week for its LC patients right?
A swiss member asked for access and they gave him a quote of roughly 120 000$ per 2 year contract in Switzerland. Just the mediciation, not ambulance costs etc (NOT EU)

 

[Redtruck99]

That is awful! So they don't have good insurance coverage in Argentina, even after it's approved? I was hoping if good reports came out after approval, it would lead to expanded access or expedited FDA approval.

 

[Cipher]

I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

You might find helmithic therapy interesting, you can read more about it here:
https://pubmed.ncbi.nlm.nih.gov/25472634/
https://www.nytimes.com/2016/06/19/magazine/the-parasite-underground.html
https://helminthictherapywiki.org/wiki/Helminthic_therapy_personal_stories#Multiple_sclerosis_(MS)
https://helminthictherapywiki.org/wiki/Helminthic_Therapy_Wiki

 

[Alvin2]

So they want to test it on long covid where there is no background that it will work but no on ME/CFS patients that have small scale successes behind it.
If they are the same disease it might work for both but go for the low hanging fruit first, not the long shot.