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AIM ImmunoTech Announces Update on Ampligen Long Covid Development Program

Treeman

Senior Member
Messages
799
Location
York, England
AIM ImmunoTech Announces Update on Ampligen Long Covid Development Program - Solve ME/CFS Initiative (solvecfs.org)

A Phase 3 prospective, double-blind, randomized, placebo-controlled trial of Ampligen in ME/CFS (AMP-516) produced improvement in exercise tolerance. An analysis of a subset of patients in that trial with early onset of symptoms showed a statistically significant 51.2% positive response

(301) Ampligen: A General Overview and the Plan for ME/CFS & Long Covid - YouTube


I may be late to the game, so apologies if this has already been shared.
 

SlamDancin

Senior Member
Messages
557
Is there nothing else in the FDA catalogue or amongst natural products that works like Ampligen? I believe it’s a TLR3 agonist.
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,112
Location
australia (brisbane)
Is there nothing else in the FDA catalogue or amongst natural products that works like Ampligen? I believe it’s a TLR3 agonist.
There are different immunotherapies used for other conditions, I'm sure there's ways to increase nk function.
Was a research Dr in Australia who treated MS by extracting the pts T cells and hyping them up somehow to fight ebv and then reinfuse the T cells. I recall he was experimenting on only 1 pt at the time and put them into remission. There is a few posts on here about this Australian researcher.
I think treatments like above are possible but getting them approved and cost etc would be too much. Maybe getting a drug indicated for one specific abnormality might be easier like low nk function or T cell function but for just a diagnosis of cfsme, I'm not sure much at all will be specifically prescribed because cfs isn't really well diagnosed or abnormalities aren't recognised like low nk function, which has even known for over 30yrs.
 
Messages
29
There are different immunotherapies used for other conditions, I'm sure there's ways to increase nk function.
Was a research Dr in Australia who treated MS by extracting the pts T cells and hyping them up somehow to fight ebv and then reinfuse the T cells. I recall he was experimenting on only 1 pt at the time and put them into remission. There is a few posts on here about this Australian researcher.
I think treatments like above are possible but getting them approved and cost etc would be too much. Maybe getting a drug indicated for one specific abnormality might be easier like low nk function or T cell function but for just a diagnosis of cfsme, I'm not sure much at all will be specifically prescribed because cfs isn't really well diagnosed or abnormalities aren't recognised like low nk function, which has even known for over 30yrs.

That was Dr. Michael Pender. The ATA188 T cell treatment for EBV in MS was picked up by Atara Biosciences and is now in phase 2 trial, with plans to start phase 3 announced. Patients in the trial re reporting good results. Published results look good. Here's a profile on it https://bit.ly/3mIHYmz

I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

There's much overlap between MS, ME/CFS, and Long Covid, in particular, latent and reactivating viruses, especially EBV, but many other viruses may be contributing to the pathology.
 

mitoMAN

Senior Member
Messages
628
Location
Germany/Austria
That was Dr. Michael Pender. The ATA188 T cell treatment for EBV in MS was picked up by Atara Biosciences and is now in phase 2 trial, with plans to start phase 3 announced. Patients in the trial re reporting good results. Published results look good. Here's a profile on it https://bit.ly/3mIHYmz

I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

There's much overlap between MS, ME/CFS, and Long Covid, in particular, latent and reactivating viruses, especially EBV, but many other viruses may be contributing to the pathology.
sadly I expect ATA-188 to cost well over 100k$ off label for ME/CFS :(
 
Messages
29

mitoMAN

Senior Member
Messages
628
Location
Germany/Austria
In Argentinia its approved but not on the market and not covered by insurance (my relative lives there)
Sadly. That was the status of mid 2021 I believe.

I doubt anyone there could afford it anyways haha. The clinical trial charged 1000$ per week for its LC patients right?
A swiss member asked for access and they gave him a quote of roughly 120 000$ per 2 year contract in Switzerland. Just the mediciation, not ambulance costs etc (NOT EU)
 
Messages
29
That is awful! So they don't have good insurance coverage in Argentina, even after it's approved? I was hoping if good reports came out after approval, it would lead to expanded access or expedited FDA approval.
 

Cipher

Administrator
Messages
933
I'm the research lead for Society With MS a patient led volunteer non-profit. In our database we are tracking all the trials and therapies that can cure MS or repair MS damage. There are 2 tabs at the bottom, All Therapies (over 100) and Trial Finder (32 that are in tirals) including if it is for EBV, and expected phase 4 date when it can be prescribed. https://bit.ly/3wJC0WK

You might find helmithic therapy interesting, you can read more about it here:
https://pubmed.ncbi.nlm.nih.gov/25472634/
https://www.nytimes.com/2016/06/19/magazine/the-parasite-underground.html
https://helminthictherapywiki.org/wiki/Helminthic_therapy_personal_stories#Multiple_sclerosis_(MS)
https://helminthictherapywiki.org/wiki/Helminthic_Therapy_Wiki
 

Alvin2

The good news is patients don't die the bad news..
Messages
3,036
So they want to test it on long covid where there is no background that it will work but no on ME/CFS patients that have small scale successes behind it.
If they are the same disease it might work for both but go for the low hanging fruit first, not the long shot.
 

Dude

Senior Member
Messages
190
OCALA, Fla., July 10, 2023 — AIM ImmunoTech Inc. (NYSE American: AIM) (“AIM”) today announced it has enrolled and dosed the first subject in the company’s Phase 2 study evaluating Ampligen® as a potential therapeutic for people with post-COVID conditions (“AMP-518”). This important study milestone follows on the heels of the company having recently opened multiple clinical study sites and having screened numerous subjects. Study screening is ongoing and AIM expects to dose additional new subjects in the coming weeks. For more information about AMP-518, please visit ClinicalTrials.gov and reference identifier NCT05592418.

https://aimimmuno.com/aim-immunotec...n-for-the-treatment-of-post-covid-conditions/
 

Judee

Psalm 46:1-3
Messages
4,515
Location
Great Lakes
https://classic.clinicaltrials.gov/ct2/show/NCT00215813

So for this one it says:

Edit: :( "Patients enrolled in the study are responsible for costs related to the therapy, e.g., drug cost, infusion cost, cost of supplies, diagnostic and other laboratory testing." What????

And above that: "The FDA approved the study for cost recovery." ??? (I'm sorry but what does that mean???)
 
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