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AIDS drug fights herpes virus

Montreal, Canada
AIDS drug fights herpes virus
I came across this news in The Times of India about a study published in PNAS. Since a lot of us seem to have herpes viruses I thought it might be of interest to post.


A drug approved in 2007 for the treatment of AIDS raltegravir or Isentresscould also play a role in preventing the herpes virus, found a new study.

Sold by Merck, the drug cancels the function of an essential protein for the replication of one kind of herpes virus, said scientists at the Institute for Research in Biomedicine (IRB Barcelona).

Headed by the coordinator of the Structural and Computational Biology Programme, Miquel Coll, the study is the first step towards the development of a drug against the entire herpes virus family.

"These results have a clear medical impact for three reasons. First, humans do not have the viral protein that is affected, thus this would allow a highly specific drug that does not show the secondary effects that other drugs may have. Second, the inhibitor is not toxic for humans when administered at therapeutic concentrations because it is already on the market and thus toxicity tests are facilitated; and third, we have data that indicate that all herpes viruses have this protein. Therefore, it could be a valid target against all Herpesviridae," explained Miquel Coll, also a CSIC research professor.

The drug cancels the function of an essential protein for the replication of the virus.

Herpesviruses include pathogens such as herpes simplex 1 and 2, the virus that causes chickenpox otherwise known as zoster virus, the Epstein-Barr virus associated with several types of cancer -, the roseola virus, the cytomegalovirus and the herpes virus associated with Kaposi sarcoma in AIDS patients.

The study is published in the journal Proceedings of the National Academies of Sciences (PNAS).


Senior Member
Very interesting indeed, many thanks for you find. I personally experienced symptoms of all these bugs which so (inevitably) confused my GP.