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Adamantane and derivatives

frozenborderline

frozenborderline

Senior Member
Messages
4,405
I have been reading up on adamantane and it’s derivatives recently. They seem to have a broad range of effects that could be useful in ME/CFS, as well as being just generally very interesting.

Adamantane itself is a diamondoid!
It is not yet used in medicine But is under development for use in HIV
https://en.wikipedia.org/wiki/Adamantane
https://raypeatforum.com/community/threads/diamant-adamantane-solution-for-lab-r-d.16108/

Bromantane is used for having both psychostimulant and anxiolytics properties, with none of the side effects of usual psychostimulants. Memantine is a dopamine agonist and nmda antagonist used in Parkinson’s.

Someone suggested to me that adamantane could have similar effects to c60 oil or buckyballs.

It seems like there’s been some study of adamantane itself and it even antagonized p2x7 receptors—purinergic signaling is a possible target for me/cfs drugs according to Naviaux
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721772/



Has anybody had experience with this drug or family of drugs?
 
frozenborderline

frozenborderline

Senior Member
Messages
4,405
..The (hetero)adamantane scaffold might play a decisive role in the three-dimensional adjustment of the pharmacophors of the abovementioned natural products and natural-product inspired compounds. It is clear that the sheer activity of a drug, exerted by the fit into a receptor's binding pocket, the active site, is essentially triggered by this three-dimensional structure. This has historically been described as the “key-lock” principle and nowadays carries the moniker “induced fit”, expressing a more dynamic understanding of the receptor-ligand interactions."
 
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