My response is to discuss cortisol testing, how I test to make sure I'm not allergic to supplements or foods before I eat them, and how to raise cortisol without hydrocortisone.
So I have multiple endocrine system issues, and the opposite problem, which is that I make too much cortisol. My doctor also said it's possible that I have MCAS. I have symptoms of it, but haven't been properly tested for it, and wouldn't be considered severe.
Here is how my endocrinologist handled cortisol testing for me, though I need my CFIDS doc to interpret it, since she uses a different range for interpretation. I did the blood testing at 8:30 a.m. for cortisol. And then she had me do cortisol saliva testing at 11:30 p.m. for two nights in a row. So I now will be able to compare these two results.
I see a holistic doc with an MD educational background who does kinesiology (aka muscle testing) on me to see if I can tolerate or if I am allergic to a food or supplement, what brand of the supplement may work best on me, and what the dosage should be. This works for anything I can hold in my hand, and I will use this before I start a new supplement. She is also the one who found me a supplement that helped with my symptoms related to too high histamine.
My cortisol levels are controlled with a supplement I take. I know it works since my cortisol levels have gone down from 600 to just under 400, with 400 being the highest end to be considered within limits for a range my endocrinologist would use.
The treatment to improve cortisol in those who can't take hydrocortisone is in one of the books my CFIDS docs use,
From Fatigued to Fantastic!, written by Dr. Jacob Teitelbaum, an internist and the former medical director of the Fibromyalgia and Fatigue Centers. He recommends vitamin C, pantothenic acid, licorice if you don't have high blood pressure, and chromium. It's on pgs. 90-91 of the 3rd ed. of the book.
Dr. Teitelbaum has multiple things written in his blog addressing adrenals and cortisol, and there is mention of ACTH in at least one of them here:
https://www.vitality101.com/health-a-z-articles/2
I wish you the best with your decisions and treatment.