The intracellular half-life is not what determines dosing in this case- it is the bioavailability and elimination kinetics that makes multiple doses a recommendation in order to optimize intracellular levels of the drug.
Not true. Drug resistance to anti-herpesviral drugs is well documented and is quite common with long-term use. HIV is not an RNA virus, it is a retrovirus, which is neither an RNA virus nor a DNA virus under the Baltimore classification.
Both acyclovir and ganciclovir are chain-terminators. Acyclovir is not effective against CMV, neither in vitro nor in vivo.
I hope this clarifies.
Intracellular half-life is what matters, not plasma half-life. That's why AZT was originally prescribed every 4 hours and then they discovered the half-life of the active drug
"The short plasma half-life and concentrations of zidovudine do not accurately reflect the more robust intracellular concentrations of the zidovudine phosphorylated forms."
Source:
Science direct zidovudine info
Immunocompetent resistance is rare, less than 1%. People with ME/CFS I would still generally consider immunocompetent but they are having a hell of a time with their metabolic system (mitochondria fracturing etc).
"In spite of the distribution of over 2.3 × 106 kg of these nucleoside analogues, the prevalence of acyclovir resistance in herpes simplex virus isolates from immunocompetent hosts has remained stable at approximately 0.3%. In immuncompromised patients, in whom the risk for developing resistance is much greater, the prevalence of resistant virus has also remained stable but at a higher level, typically 4 to 7%. "
Source:
NIH ayclovir and penciclovir resistance rates
Acyclovir is a direct chain terminator, not gancicloivr or penciclovir, they are poor chain substrates.
ganciclovir triphosphate serves as a poor substrate for chain elongation -
https://en.wikipedia.org/wiki/Ganciclovir. Notice it can still elongate or continue to link new nucleosides.
I know you're not supposed to source wiki but who cares
Penciclovir triphosphate acts as a competitive inhibitor of the natural substrate required for viral DNA replication,
but does not irreversibly terminate DNA replication. Penciclovir sciencedirect
ACVTP competes with naturally occurring nucleoside triphosphates and is incorporated into the elongating viral DNA chain as it replicates, resulting in chain termination
Acyclovir Sciencedirect
I've consumed all those drugs including several HIV drugs. Not trying to be better than you but people should know the right information.
I've experienced the worst symptoms of ME/CFS where I was laid up in a bed for days at a time and had to break every 30 minutes just so I could work for 45 mins in my house. I'm talking from a consumer who is knowledgeable.
