TL;DR: Desipramine could be Abilify alternative, it has only 3 reports on PR and all are positive, one person apparently got into remission from it. More at the end.
I think I know why abilify stops working and I already talked about this with @Hip . I'll start by saying that receptor down regulation theory doesn't make sense to me, because:
1) It takes at least 3 months to happen, witch I think is very long compared to benzodiazepines.
2) I don't know other meds where there are only two groups of people when it comes to tolerance, you either develop it and it never goes away OR you don't experience it at all!
So what is the reason for tolerance in my opinion?
- It's bacterial resistance that happen in some people, because of the specific strains they carry as their pathogenic bacteria that causes their me/cfs. Basically it's the same reason why long term antibiotic courses cause bacterial resistance to form.
Wft am I talking about?
- I think abilify helps by it's antibacterial properties, specifically it is connected to Dr. Markov's me/cfs hypothesis (see here)
Abilify has antibacterial properties:
But this theory is no good if we can't prove it right or wrong, luckily, we should be able to do this relatively easy, just need a few patients who developed tolerance to Abilify to try Desipramine.
Desipramine has only 3 reports on PR and all are positive, one person apparently got into remission. Desipramine has significantly more antibacterial activity then abilify according to this figure, so might be even better then Abilify and it also has less side-effects - https://www.nature.com/articles/s41598-020-74934-9/figures/5
I think I know why abilify stops working and I already talked about this with @Hip . I'll start by saying that receptor down regulation theory doesn't make sense to me, because:
1) It takes at least 3 months to happen, witch I think is very long compared to benzodiazepines.
2) I don't know other meds where there are only two groups of people when it comes to tolerance, you either develop it and it never goes away OR you don't experience it at all!
So what is the reason for tolerance in my opinion?
- It's bacterial resistance that happen in some people, because of the specific strains they carry as their pathogenic bacteria that causes their me/cfs. Basically it's the same reason why long term antibiotic courses cause bacterial resistance to form.
Wft am I talking about?
- I think abilify helps by it's antibacterial properties, specifically it is connected to Dr. Markov's me/cfs hypothesis (see here)
Abilify has antibacterial properties:
https://www.nature.com/articles/s41598-020-74934-9
But this theory is no good if we can't prove it right or wrong, luckily, we should be able to do this relatively easy, just need a few patients who developed tolerance to Abilify to try Desipramine.
Desipramine has only 3 reports on PR and all are positive, one person apparently got into remission. Desipramine has significantly more antibacterial activity then abilify according to this figure, so might be even better then Abilify and it also has less side-effects - https://www.nature.com/articles/s41598-020-74934-9/figures/5
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