A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.

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kelly posted this to co-cure today

[if: ???? does sound a bit pavlovian]

*A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.*

Tanaka M, Watanabe Y.

Department of Physiology, Osaka City University Graduate School of Medicine,
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

Chronic fatigue syndrome is an illness characterized by a profound,
disabling, and unexplained sensation of fatigue lasting at least 6months,
which severely impairs daily functioning and is accompanied by a combination
of non-specific symptoms.

Many potential causes of chronic fatigue syndrome
have been investigated, including viral infections, immune dysfunctions,
abnormal neuroendocrine responses, central nervous system abnormalities,
autonomic dysfunctions, impaired exercise capacities, sleep disruptions,
genetic backgrounds, psychiatric abnormalities, personality, and abnormal
psychological processes. However, no etiology, specific physical signs or
laboratory test abnormalities have been found.

It is essential to establish
a conceptual theory of chronic fatigue syndrome that can explain its
pathophysiology in order to identify the clinical entity and to develop
effective treatment methods. In this article, a new conceptual hypothesis
about the pathophysiology
of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress)
.

In the future, a new
treatment strategy for patients with chronic fatigue syndrome,
re-co-conditioning therapy, may be developed on the basis of the
co-conditioning theory. In addition, this theory will likely contribute to a
better understanding of the pathophysiology of chronic fatigue syndrome.

Med Hypotheses. 2010 Mar 23. [Epub ahead of print]

Copyright 2010 Elsevier Ltd. All rights reserved.
 

MEKoan

Senior Member
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I sometimes teach meditation. I'm always wondering how I could use meditation to address ME. I would like to become a Laughter Yoga Leader and use Laughter Yoga with people with ME. (No, I can't stay upright long enough to do any of the above but, for the purposes of this post, that's beside the point :D )

I'm not surprised when people in various disciplines try to apply their education, theories and techniques to ME. Sometimes it's a good hearted effort. Sometimes it's drumming up business. And, sometimes, when people are employed by international insurance companies or governments reluctant to pay benefits, it's something darker.

I don't know what this is except it seems old fashioned and wrong headed. Haven't we already mined this ground for all it's worth?
 

Dolphin

Senior Member
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I read somebody's critique of this paper (can't be reposted unfortunately). They weren't impressed.
They said: "Treatment is CBT/GET to stop you resting. Then you get pleasant fatigue instead of unpleasant fatigue."
 

Dr. Yes

Shame on You
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Et tu, Osaka? I thought Japan had a more sophisticated approach to ME/CFS. Sounds like they're just beginning to discover the psycho lobby literature.

(I hope you all appreciate how hard it was for me not to post an image of Godzilla.)

:innocent1:
 

Athene

ihateticks.me
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They're not talking about us in this document, are they?
It's about people whose main symptom is an "unexplained sensation of fatigue" and other "non-specific symptoms". Not me, mate! My main symptom is post-exertional hypoxia explained by mitochondrial dysfunction, and all my other symptoms are highly specific.
I think they are just talking about over-stressed Japanese executives. People with Reeves syndrome and Wessely Disease.
 
G

Gerwyn

Guest
kelly posted this to co-cure today

[if: ???? does sound a bit pavlovian]

*A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.*

Tanaka M, Watanabe Y.

Department of Physiology, Osaka City University Graduate School of Medicine,
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.

Chronic fatigue syndrome is an illness characterized by a profound,
disabling, and unexplained sensation of fatigue lasting at least 6months,
which severely impairs daily functioning and is accompanied by a combination
of non-specific symptoms.

Many potential causes of chronic fatigue syndrome
have been investigated, including viral infections, immune dysfunctions,
abnormal neuroendocrine responses, central nervous system abnormalities,
autonomic dysfunctions, impaired exercise capacities, sleep disruptions,
genetic backgrounds, psychiatric abnormalities, personality, and abnormal
psychological processes. However, no etiology, specific physical signs or
laboratory test abnormalities have been found.

It is essential to establish
a conceptual theory of chronic fatigue syndrome that can explain its
pathophysiology in order to identify the clinical entity and to develop
effective treatment methods. In this article, a new conceptual hypothesis
about the pathophysiology
of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress)
.

In the future, a new
treatment strategy for patients with chronic fatigue syndrome,
re-co-conditioning therapy, may be developed on the basis of the
co-conditioning theory. In addition, this theory will likely contribute to a
better understanding of the pathophysiology of chronic fatigue syndrome.

Med Hypotheses. 2010 Mar 23. [Epub ahead of print]

Copyright 2010 Elsevier Ltd. All rights reserved.
Methinks he wantabe rich and wantabe shot is it Tan AKA wesselly
 

Jerry S

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Et tu, Osaka? I thought Japan had a more sophisticated approach to ME/CFS. Sounds like they're just beginning to discover the psycho lobby literature.

(I hope you all appreciate how hard it was for me not to post an image of Godzilla.)

:innocent1:
Dear Dr. -

Do not constrain thyself.

Best wishes,

A congregant of the Church of FIB
 

fingers

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They're not talking about us in this document, are they?
It's about people whose main symptom is an "unexplained sensation of fatigue" and other "non-specific symptoms". Not me, mate! My main symptom is post-exertional hypoxia explained by mitochondrial dysfunction, and all my other symptoms are highly specific.
I think they are just talking about over-stressed Japanese executives. People with Reeves syndrome and Wessely Disease.
Agree, Athene, I think this is the root of the problem. We need to get away from "fatigue".

The stuff Tomk posted about clinician training was centred around this too.

Unfortunately, it's even the central part of the name now....CFS

How about we retain CFS, but change it to Continually Feeling Shit ?

CALL TO ACTION : Whatever you do, don't tell 'em you're tired.

F
 
G

Gerwyn

Guest
Agree, Athene, I think this is the root of the problem. We need to get away from "fatigue".

The stuff Tomk posted about clinician training was centred around this too.

Unfortunately, it's even the central part of the name now....CFS

How about we retain CFS, but change it to Continually Feeling Shit ?

CALL TO ACTION : Whatever you do, don't tell 'em you're tired.

F
how about dropping the name altogether
 

fingers

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how about dropping the name altogether
Agree too Gerwyn, just trying to add a touch of humour (in the absence of intelligence on my part).

What do you think the name should be (maybe XAND for some soon, but will then need a name for "the rest").

How important do you think the name is and how feasible is it to achieve a change?

To my mind (restating what I said previously), definitions, classifications and diagnosis are at the root of misunderstandings about appropriateness of psychiatric approaches. The whole thing is inadequate, and the inability of the medical profession to grasp this problem and to solve it is woeful.
 

PoetInSF

Senior Member
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In this article, a new conceptual hypothesis
about the pathophysiology
of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress)
.
There could be something to this, given that many of us are hyper-reactive to stress, exertion, chemical or stimuli. But I would question how we get into that conditioned state to begin with. It could be an injury by one time stress, like viral infection or other trauma, as well as conditioning by repeated stress.
 
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It sounds like that vaunted Japanese effort is striking out. They didn't have much to report at the IACFS/ME conference either.
What? Because two people who happen to be Japanese write a paper in Medical Hypotheses that means the entire country's efforts are "striking out"? This makes no sense.
 
G

Gerwyn

Guest
Agree too Gerwyn, just trying to add a touch of humour (in the absence of intelligence on my part).

What do you think the name should be (maybe XAND for some soon, but will then need a name for "the rest").

How important do you think the name is and how feasible is it to achieve a change?

To my mind (restating what I said previously), definitions, classifications and diagnosis are at the root of misunderstandings about appropriateness of psychiatric approaches. The whole thing is inadequate, and the inability of the medical profession to grasp this problem and to solve it is woeful.
psychatrists dontmake diagnoses only real doctors do that.psychiatrists just categorise and stigmatize
 

fingers

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It is essential to establish
a conceptual theory of chronic fatigue syndrome that can explain its
pathophysiology in order to identify the clinical entity and to develop
effective treatment methods. In this article, a new conceptual hypothesis
about the pathophysiology of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress).
Is it me, or am the above nor English....maybe Japanese?

There could be something to this, given that many of us are hyper-reactive to stress, exertion, chemical or stimuli. But I would question how we get into that conditioned state to begin with. It could be an injury by one time stress, like viral infection or other trauma, as well as conditioning by repeated stress.
FWIW - here's finger's feory (UK has now dispensed with "th" in favour of "f" - they teach this in schools - my nickname is actually thingers).........

When we're happy and swinging along we don't get ill.

So, if we're infected with HIV, maybe it hangs around waiting until we're below par, then does it's stuff. Maybe same with XMRV.

However, once "lifetime" hitchhikers such as these get in there, we can't get rid of them. It doesn't matter if we reduce our stress to zilch, eat well, rest - we can feel better, sure, but the underlying condition doesn't change - unlike having "temporary" viruses such as a cold, or more benign lifetime ones like herpes.

So, psycho approaches can only help with temporary infections, or problems with a psychiatric bias, and these things may simply go away anyway, so difficult to prove efficacy of the approach.

T
 
G

Gerwyn

Guest
Hello Fingers et al.

Good name, Fingers!

The point is that drs cant access unbiased information about cfs .i cant see any Dr googling this area when they have been indoctrinated by the psychos.We cant stop others labelling us but we need not use it ourselves.Other groups have successfully rebranded themselves why cant we?We both know the power of words.
 

fingers

Senior Member
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Hello Fingers et al.

Good name, Fingers!

The point is that drs cant access unbiased information about cfs .i cant see any Dr googling this area when they have been indoctrinated by the psychos.We cant stop others labelling us but we need not use it ourselves.Other groups have successfully rebranded themselves why cant we?We both know the power of words.
I'm with you, Gerwyn, lets agree a name on this forum (I thiink we could achieve a consensus within 12 months max :cool:).

Also, people often quote the WHO definition of Myalgic Encephalomyelitis (although Phil Parker drops the "omyel" probably due to doing dyslexia). This has legal meaning, but not much else it seems.

I'll start the ball rolling with UNID (unidentified neuroimmune disease).

Offers?

Dr.Yes, get back to your own thread.

F