kelly posted this to co-cure today
[if: ???? does sound a bit pavlovian]
*A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.*
Tanaka M, Watanabe Y.
Department of Physiology, Osaka City University Graduate School of Medicine,
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Chronic fatigue syndrome is an illness characterized by a profound,
disabling, and unexplained sensation of fatigue lasting at least 6months,
which severely impairs daily functioning and is accompanied by a combination
of non-specific symptoms.
Many potential causes of chronic fatigue syndrome
have been investigated, including viral infections, immune dysfunctions,
abnormal neuroendocrine responses, central nervous system abnormalities,
autonomic dysfunctions, impaired exercise capacities, sleep disruptions,
genetic backgrounds, psychiatric abnormalities, personality, and abnormal
psychological processes. However, no etiology, specific physical signs or
laboratory test abnormalities have been found.
It is essential to establish
a conceptual theory of chronic fatigue syndrome that can explain its
pathophysiology in order to identify the clinical entity and to develop
effective treatment methods. In this article, a new conceptual hypothesis
about the pathophysiology of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress).
In the future, a new
treatment strategy for patients with chronic fatigue syndrome,
re-co-conditioning therapy, may be developed on the basis of the
co-conditioning theory. In addition, this theory will likely contribute to a
better understanding of the pathophysiology of chronic fatigue syndrome.
Med Hypotheses. 2010 Mar 23. [Epub ahead of print]
Copyright 2010 Elsevier Ltd. All rights reserved.
[if: ???? does sound a bit pavlovian]
*A new hypothesis of chronic fatigue syndrome: Co-conditioning theory.*
Tanaka M, Watanabe Y.
Department of Physiology, Osaka City University Graduate School of Medicine,
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Chronic fatigue syndrome is an illness characterized by a profound,
disabling, and unexplained sensation of fatigue lasting at least 6months,
which severely impairs daily functioning and is accompanied by a combination
of non-specific symptoms.
Many potential causes of chronic fatigue syndrome
have been investigated, including viral infections, immune dysfunctions,
abnormal neuroendocrine responses, central nervous system abnormalities,
autonomic dysfunctions, impaired exercise capacities, sleep disruptions,
genetic backgrounds, psychiatric abnormalities, personality, and abnormal
psychological processes. However, no etiology, specific physical signs or
laboratory test abnormalities have been found.
It is essential to establish
a conceptual theory of chronic fatigue syndrome that can explain its
pathophysiology in order to identify the clinical entity and to develop
effective treatment methods. In this article, a new conceptual hypothesis
about the pathophysiology of chronic fatigue syndrome, the co-conditioning
theory, is presented: after repetitive overwork and/or stress, alarm signal
to rest and fatigue sensation may cause in response to an unconditioned
stimulus (impaired homeostasis and function) that has been paired with a
conditioned stimulus (overwork and/or stress).
In the future, a new
treatment strategy for patients with chronic fatigue syndrome,
re-co-conditioning therapy, may be developed on the basis of the
co-conditioning theory. In addition, this theory will likely contribute to a
better understanding of the pathophysiology of chronic fatigue syndrome.
Med Hypotheses. 2010 Mar 23. [Epub ahead of print]
Copyright 2010 Elsevier Ltd. All rights reserved.