I find this view interesting. Could you expand a little on it? Do you think ME is basically a brain disorder of some kind? Where do you think the "danger signals" are coming from or what causes them? Thanks!
Sure. I think ME is a gating problem in the brain/CNS, driven by excessive Long Term Potentiation and NMDA signaling, resulting in many signals given inappropriate salience/relevance/importance.
Now, the body has many danger signals, for example, extracelular potassium is a signal for hypoxia, extracelular ATP, the kinins etc... are also compounds produced by stressed cells. I dont think that they are overproduced in the body, rather the ME body overreacts to physiological amounts of these signals, resulting in the familiar, yet nonspecific symptoms of feeling inflamed, infected, toxic, as well as the ANS not working correctly.
This also explains why study after study finds no obvious biochemical difference between controls and PwME. With this theory it also makes sense why gabapntin, clonazepam, phentoiyn, lamotrigine, topiramate, low dose abilify, cabergoline (and other D2 agonists) etc... can result in striking symptomatic improvement for some people. They all modulate aberrant nmda signaling.
There is one thing that im still integrating, and thats the lymph node swelling and pain.