A monitor to test for mitochondria PO2

[kangaSue]

Don't know if this is available commercially but came across mention of a clinical monitor (COMET) that can measure mitochondrial oxygen and oxygen consumption via a cutaneous probe;

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655595/
A monitor for Cellular Oxygen METabolism (COMET): monitoring tissue oxygenation at the mitochondrial level
[CONCLUSION.
This report provides a description of the novel COMET measurement system. The enhanced protoporphyrin IX concentration in the skin is used as endogenous oxygen-sensitive probe. The method gives the possibility to measure cellular oxygen availability and the oxygen disappearance rate at the bedside on a mitochondrial level. In the future the COMET could play a role in clinical practice to assess tissue viability, to manage oxygen transport, and to recognize and possibly to treat mitochondrial inhibition in critically ill patients. Furthermore it potentially can be used as an individual blood transfusion trigger and may enable testing mitochondrial effects of pharmaceutical substances research.]

 

[Learner1]

No, but let us know if you find one! I've had mito function testing, muscle biopsy, small fiber neuropathy biopsy, nerve conduction studies and tests for oxidative and nitrosative stress.

The only thing I know to do at the moment us to try interventions as I've been doing, mito nutrients, phospholipids, glutathione, PEMF and HBOT and repeat the mito function testing, which measures respiratory rate through each complex, and to monitor lipid peroxides, 8OHdG, glutathione status, and nitrotyrosine. And to monitor how much my NAD+, pantethine, riboflavin, and BCAAs, particularly leucine, my body is consuming.

A more convenient, real-time tool would be welcome.

And I'm open to suggestions on how to do this any better, but I seem to be getting results with the approach, which has been trial and error

 

[Wishful]

One limitation of the test is that it only tests mitochondria in the skin. My suspicion is that ME involves dysfunction of cerebral mitochondria, and the test would be counterproductive for that (false negative results if you aren't aware of the limitation).

I have ME, and I don't see any indications of mitochondrial dysfunction in my muscle tissues. For those with obvious muscle mito dysfunction, I suppose the test could be useful for testing treatments.

 

[xrayspex]

No, but let us know if you find one! I've had mito function testing, muscle biopsy, small fiber neuropathy biopsy, nerve conduction studies and tests for oxidative and nitrosative stress.

The only thing I know to do at the moment us to try interventions as I've been doing, mito nutrients, phospholipids, glutathione, PEMF and HBOT and repeat the mito function testing, which measures respiratory rate through each complex, and to monitor lipid peroxides, 8OHdG, glutathione status, and nitrotyrosine. And to monitor how much my NAD+, pantethine, riboflavin, and BCAAs, particularly leucine, my body is consuming.

A more convenient, real-time tool would be welcome.

And I'm open to suggestions on how to do this any better, but I seem to be getting results with the approach, which has been trial and error

hi Learner1! I am getting closer to trying HBOT--wanted to refresh memory on whether it causes any herxing for some CFSers? I also have a slight fear that it could change pressure around my head and somehow worsen headaches or pain....have you seen or heard of anything like that? I had another concussion earlier this summer so seems like it could be helpful if all goes well tho............

 

[Learner1]

I have heard of people herxing, but I have had no problems with it even when my infections were worse.

Occasionally, I've gotten a "sick headache" after being in there a while (45-60 minutes) which I've taken as a sign that I've been in l9bf enough. It goes away pretty quickly with no lingering effects.

It has good effects with TBIs, particularly when used with nutrients.