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According to the metabolic trap theory, excess tryptophan is converted to serotonin and when serotonin level gets high, the body adjusts itself to high serotonin environment reducing serotonin receptor numbers to reduce sensitivity to serotonin.
Serotonin receptor abnormality is at the centre of irritable bowel syndrome.
https://www.ncbi.nlm.nih.gov/pubmed/24425100
Just as a quick aside question regarding the Serotonin issues - after 5 years of seriously severe bloating 24/7 my gastro finally found a pill that works to combat it - it's called Prucalopride. It's a high affinity serotonin (5-HT4) receptor agonist. It's supposed to be a last hope med for those with incurable constipation. It works wonders for my bloating, but I've noticed my energy levels getting worse since I started taking it, with crashes coming way more frequently and easily and my overall condition getting quite a bit worse. Does anyone know if this medicine would be contraindicated with the Serotonin hypothesis with ME/CFS?
Thanks in advance