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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I know that methylfolate directly interacts with COMT, thus I wouldnt recommend methylfolate.With all that COMT maybe HB12 would be better.
I have many CFS s ymptoms, plus many more. I'm not sure if this could be causing my issues, or just part of it. Could anyone please help and advise?
The reason why I would start with mb12 is because:
-he has MTHFR -> low methylfolate -> very few methyl-groups
-Also he has COMT so methylfolate would increase Dopamine
-But due to MTHFR, methyl groups are missing and needed.
-ppl with COMT may have problems with methyl-b12
If I take all this together, I logically come to the conclusion, that I would try a low methyl-b12 dose.
Wouldnt you agree?
Low MTHFR does not indicate lower levels of methyl groups.The reason why I would start with mb12 is because:
-he has MTHFR -> low methylfolate -> very few methyl-groups