23andme results help needed :)

C

Cookie27

Messages
25
Hello,

I have received results for my sons 23.me. I was wondering if anyone could help me with the results?
He has been quite challenging since he was 2 years old. Very intelligent boy but sometimes he is just very difficult to manage. I have used Yasko site to interpret 23me raw data. Would love some insight cheers

COMT V158M +/+
COMT H62H +/+ TT
COMT 61 -/-
VDR Taq Tt
VDR Fok Ff
MAO A R297R +/+ TT
ACAT 1-02 +/-
MTHFR C677T +/-
MTRR 11 +/- CBS C699T +/-
CBS A360A +/+ AA
 
V

Valentijn

Senior Member
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15,786
MTHFR C677T +/- means that enzyme activity is reduced to 65% of optimum. But due to the MTHFR mutations being extremely common, the average is 70%, which makes you pretty normal. The rest of those SNPs are pretty irrelevant.
 
C

Cookie27

Messages
25
Valentijn said:
MTHFR C677T +/- means that enzyme activity is reduced to 65% of optimum. But due to the MTHFR mutations being extremely common, the average is 70%, which makes you pretty normal. The rest of those SNPs are pretty irrelevant.
Click to expand...

COMT and MAO Homozygous is irrelevant? now I am confused.
 
V

Valentijn

Senior Member
Messages
15,786
Cookie27 said:
COMT and MAO Homozygous is irrelevant? now I am confused.
Click to expand...
Two of those SNPs are completely irrelevant. COMT H62H and MAOA R297R do nothing. COMT V158M has an impact on that gene, but there's no connection with methylation demonstrated, just the usual baseless speculation.
 
C

Cookie27

Messages
25
Valentijn said:
The symbol for the protein before and after the position number is the same. Hence those SNPs are in coding regions of the gene, but result in no change to the protein.
Click to expand...

Thanks again for your reply.. could you point towards studies regarding the above.. I would love to read about it .. cheers.
 
V

Valentijn

Senior Member
Messages
15,786
Cookie27 said:
Thanks again for your reply.. could you point towards studies regarding the above.. I would love to read about it .. cheers.
Click to expand...
It's basic genetics. Synonymous variants won't have an impact. Coursera has some introductory classes which will help with these concepts.
 
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