23andme genetic testing

rwac

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If you're interested in getting a genetic test, like the genova DetoxiGenomic panel, this might also be of interest to you.
You get a lot of data (1 Million SNPs!), but you have to do most of the analysis yourself.

Anyway, there's a sale on monday 4/11/2011, you can get it for Shipping+1 yr subscription. ($9x12)

It includes MTHFR, some VDR, Cytochrome P450, Gilbert's etc.

I have personally found it quite useful.

https://www.23andme.com
 

camas

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It includes MTHFR, some VDR, Cytochrome P450, Gilbert's etc.

I have personally found it quite useful.

https://www.23andme.com
Rats! I paid the full $200 a few weeks ago. They did process it quickly though.

I filled out some of the optional surveys and FM and CFS came up on the first one! So clearly they are interested in finding genes associated with these illnesses.

I had difficulty understanding the raw data so ran it through Promethease at SNPedia. It said I was Gs192 having two variations in MTHFR which influence homocystine levels. That was the only thing that stood out for me though.

rwac, can you tell me what other genes I should be looking at? I'm clearly in over my head. :D
 

rwac

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It takes a while to understand this stuff.
Btw, I suggest you install snptips if you can. (http://snptips.5amsolutions.com/)

It lets you see immediately what genotype you are from your browser.

Here's a list of snps to start from, I don't understand them completely.
http://www.mothering.com/community/wiki/genetics-and-detoxification

Other interesting things I have found:
SNPs on BCMO1 which controls conversion of beta-carotene to retinol.
http://www.snpedia.com/index.php/BCMO1

Rs7501331 = T and
Rs12934922 = T correspond to lower serum retinol.

Gilbert's Syndrome is something that's more prevalent among us CFS folks.
It affects the enzyme UGT1A1 which excretes bilirubin, estrogen and other toxins/medicines.
See this thread: https://www.23andme.com/you/community/thread/3176/

There's desaturases (FADS1, FADS2) which convert plant-source omega-3 and omega-6 fats to DHA/Arachidonic acid. You will need more animal fats if you have snps on these enzymes.
One such is Rs174537 = TT near FADS1 which is correlated with lower conversion of linoleic acid and alpha-linoleic acid to other Omega-6 and Omega-3 fats.

That would mean that Rs174537(TT) people need to get more of both Omega-6 and Omega-3 animal fats.
 

penny

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Thanks for the info on the sale Rwac!

I've been wanting to get genetic testing since reading an article about the company years ago, before I got sick or had any practical reason to. But it started out a lot more expensive (especially since I wasn't ill at the time) and I didn't realize how much it had come down in price! Also thinking it'll make a perfect birthday present for my dad, who is basically of good health but still very interested in such things. We joked about getting the 'family discount' for SPECT scans at the Amen Clinic.

Now we'll just have to see if I can understand the results :)
 

camas

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Wow! Thanks so much for all of these links, rwac. I'll get right to it and see what I can make of my results.
 

rwac

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It's told me that I have MTHFR polymorphisms, so I'm not that efficient at making methylfolate. Also that I have a BH4 deficiency.
That I'm not that good at converting carotene to retinol (I already knew this). I have the markers for Gilbert's and polymorphisms in other Liver enzymes, so I have detox issues.
 

camas

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Earwax type??? :Retro tongue:

But seriously, in what way has it been helpful to you?
It told me that I have polymorphisms that lead to difficulty processing folates and convinced to continue with Rich's protocol. It gives lots of other health information too. It caught my increased risk for glaucoma and parkinsons -- two things that are in my family. I wasn't aware of an increased risk for breast cancer though, so am getting a long overdue mammogram this month.

And, if you're into genealogy, you can use the relative finder to see who matches your dna. I've found a second cousin I'd lost contact with and found a brand new fifth cousin on one of my favorite lines.
 

LaurieL

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I posted this info on the other forum and rwac kindly notifed of this thread, so here is the info.
Link please?

This chart cross references the SNP testing available from 23andme [(V2) and (V3) chip tests] to the Yasco genetic testing panel.
https://spreadsheets.google.com/ccc?..._A&hl=en#gid=0
Translation please? Do they both test the same things? Does one offer more information than the other? What are the differences?

Laurie
 

Doogle

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It shows your individual genetic tendencies. For example the VDR SNPs can show how you may respond to GcMAF.

http://phoenixrising.me/forums/show...yone-taking-it&p=107485&viewfull=1#post107485

Amy Yasko (and others) have websites devoted to these SNPs explaining how patient's mutations affect metabolic processes so persons who have been tested can tailor their nutritional supplements to their genetics. Rich Von Konynenburg's program http://phoenix-cfs.org/old_site/GSHMethylDeplTheoryJuly07.htm is partially based on the genetic testing and results of many ME/CFS patients.
 

LaurieL

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Tell me what the difference is between V2 and V3 chip testing.

From what I understand from the chart as explained from another, is that basically they both test for the same SNP's BUT.... Within each SNP, where one may test for say 7 variations, the other may only test for 6? So Yasko tests all, where as 23 and Me does not. The ones they don't, are those then considered less common or known to have less inpact?

Yasko is from blood, 23 and Me is from Saliva. Is one better than the other? What accuracy rates are associated with this particular testing?

Additionally, would say bacterial or candida presence in the mouth create any problems in the testing of saliva? There are many with such issues.

Laurie
 

rwac

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The v2 chip is old, going forward, everyone will be tested on the v3 chip.

For each SNP either 23andme tests it or not. Both yasko and 23andme would give you the same info on the SNP. Yasko would include more analysis, of course.

Now 23andme may not test some SNPs on a particular gene, for example v3 tests only 1 out of 2 CBS SNPs and 3 out of 4 COMT SNPs, and doesn't test yasko's ACE SNP. It's hard to say much about the importance of the relevant SNPs. It's good value for the money though.

Testing SNPs is supposed to be pretty accurate in general. This guy compared the data from 23andme and decodeme.
http://longavista.blogspot.com/2008/04/comparing-genome-results-from-23andme.html

I don't think candida should be a problem.
 

taniaaust1

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I havent had that test done but have had some testing done in this area and knowing that you have issues in these areas can be a very good thing.

I have a MTHFR polymorphism so that means i have the issue of only being able to absorb half amount of folate. (hence i ended up having a child with similar to spina bifida which had i known i carried this.. i could of taken extra supplements and not had her born disabled).

Those who have MTHFR polymorphism have a higher chance of miscarriage ..that too can be prevented (baby asprin is often prescriped in pregnancy if you know you have this issue).

Due to the MTHFR polymorphism I have.. i need to take folate and some special forms of B vitamins to donate methyl groups (which will hopefully lower the higher risk of me getting certain things due to it). Methylation issues are common in CFS.
 

camas

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Now 23andme may not test some SNPs on a particular gene, for example v3 tests only 1 out of 2 CBS SNPs and 3 out of 4 COMT SNPs, and doesn't test yasko's ACE SNP.
Just wanted to let you know that I had my test done just a few weeks ago and they tested both CBS SNPs.
 

rwac

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Just wanted to let you know that I had my test done just a few weeks ago and they tested both CBS SNPs.
Oops. What do you know, you're right. I have both SNPs too, but I must have missed it somehow.
Sale's almost over!