23andme genetic test, anything i need to look at?

[jay185]

Hi all,

Having suffered with a lot of CFS symptoms over the years i had a 23andme genetic test for SNPs and wondered if anyone could help me decode much from this set of results and if there is anything there that i should be aware of that means i need to supplement for something specifically. I believe somewhere i read VDR taq ++ is a problem and causes low vitamin D and possibly some serotonin/dopamine problems?

My first impression is there is not much there of concern but i could be wrong because i am not very good at reading these things. If there is anything you think needs paying attention to here please let me know, thanks for reading.

@sb4

 

[taniaaust1]

that looks good to be. Be aware that there are places online in which you can run your 24andME raw DNA data through which could give you more info.

 

[jay185]

Oh? Do you know the other websites to do this, is it free?

I am getting from your message that there isn't much to worry about regarding my result?

Thanks

 

[Carl]

Oh? Do you know the other websites to do this, is it free?

I am getting from your message that there isn't much to worry about regarding my result?

Thanks

I received a WGS from Dante Labs last month but so far have not got too much from it. The report provided was terrible and most of the free gene decode sites do not support vcf files.

From my bookmarks:

Free:
https://codegen.eu
http://geneticgenie.org
https://genomelink.io
A few very limited Free options. I have tried this but I am not impressed TBH. It does support vcf files which were the only format provided by Dante Labs.
https://sequencing.com

Most of these make a charge, however I have not checked them thoroughly
I have tried this because it does support vcf files but so far I have not been impressed. The charge is fairly small but the results are very difficult to read and require a great deal of interpretation.
https://promethease.com
https://www.dna.land
https://www.gedmatch.com/register.ph
https://livewello.com/23andM
https://www.knowyourgenetics.com
https://www.nutrahacker.com
https://www.selfdecode.com
https://genomelink.io/signup
https://www.snpedia.com/index.php/SNPedi
https://www.xcode.life

 

[Hufsamor]

I did 23andme some years ago.
And for what I could figure out on my own, everything looked rather fine.
In the end I had a doc to look at it, and he was able to point out several issues.
So it might look good enough, but it's a big jigsaw, and it's not easy to figure out on your own

 

[Wishful]

I've been reading a book on heredity. One chapter is about mosaicism: how the cells in our bodies differ in their DNA. Every time cells replicate, there's a chance of mutation, which carries on to its descendants. The earlier in a person's development, as cell lines specialize, the greater the possible effect. So, if companies like 23andme use DNA from white blood cells, the results would really only be valid for that type of cell. You could still have a genetic defect in your brain cells or skin cells which wouldn't show up. Likewise, an error in the WBC DNA that could cause problems in other types of cells, might not be an issue, because that DNA error might not exist in those other cells.

I'm not sure of how common these DNA differences are in human bodies, but it makes me wonder whether such testing is comparable to testing soil in one spot in the world: the results are only really useful for that one spot.

 

[Learner1]

You can run your file through Enlis. Go to Enlis.com/import. You should be able to upload you 23andme data using the instructions there.

23andme is only a selection of genes, but you still might find something useful. I ran mine plus my GeneDX data through and the 2 sets of data correlated well, verifying the validity of 23andme.

You might look for rare genes, or you can liok up indicidual genes researchers have associated with ME/CFS or various other health problems. I was able to find that I have gene mutations for celiac, heriditary hemochromatosis, Hashimotos, and a genetic clotting disorder, as well as several associated with ME/CFS, in affition to methylation SNPs you already found.

Then you need to figure out what to do with the info you've found.