2016 Ramsay: Research Team 1 Update February 22, 2018

[Sushi]

Dr. Jarred Younger (University of Alabama at Birmingham) recently provided Solve ME/CFS Initiative (SMCI) with a progress update on the Ramsay 2016 Research Team 1 project.Dr. Younger is using a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. He aims to describe inflammatory processes at work in the brains of individuals with ME/CFS.In the following interview, he reflects on what motivated him to study neuroinflammation in ME/CFS and how pilot grants like the Ramsay Award can jumpstart promising lines of investigation.
https://solvecfs.org/2016-ramsay-research-team-1-update/

 

[andyguitar]

I like the sound of this!!

 

[Rooney]

Did we ever know how many scans he needed on this project?

 

[Zara]

Was wondering what myo inositol is and which diseases show a peak ?

https://radiopaedia.org/articles/myo-inositol-peak


Myo-inositol is one of the compounds images with MR spectroscopy (MRS) at both 1.5T and 3T and is seen to resonate at 3.5 ppm chemical shift (right of the choline peak).

Myo-inositol is a precursor of both phosphatidylinositol (the major inositol-containing phospholipid) and of phosphatidylinositol 4,5-bisphosphate (a key molecule in cellular signal transduction). It also plays an important role in osmoregulation 3.

• elevated in
  • low grade astrocytoma
  • progressive multifocal leukoencephalopathy (PML)
  • Alzheimer's disease
  • Down syndrome 1,3
  • regions of gliosis 2
    • congenital CMV infection
• reduced in
  • hepatic encephalopathy
  • glioblastoma (WHO Grade IV astrocytoma)