1-methylhistidine extremely high, what does this mean?

[jason30]

Hi all,

This is my first post, i am reading on this forum already for a long time. Now i have decided to register, and my first action is a question about my blood results.
I am diagnosed me/cfs and fibromyalgy.

Last week i have received my results of the amino acid analysis through 24 hours urine.1-methylhistidine has been elevated alot, it's extremely high.

1-methylhistidine: 973 umol/24u (normal range: 128 - 392)
3-methylhistidine: 216 (this is good).

A google search gave me a probably leaky gut syndrome (http://www.aminoacid....com/blog/?p=11).

Can anyone tell me more about an elevated 1-methylhistidine? Can it be lowered with food/supplements?

Thanks in advance.

 

[Valentijn]

1-methylhistidine: 973 umol/24u (normal range: 128 - 392)
3-methylhistidine: 216 (this is good).

It would be elevated due to breaking down muscle or meat. It could be due to damage done to your muscles, or it could be from eating a lot of meat.

Were your beta-alanine, carnosine, and anserine levels normal?

 

[jason30]

Hi Valentijn,
Thank you for your reaction.

Hereby a summary of other amino's which are not normal:
GABA: 3 umol/24u ( 7 - 35)
Methionine: 7 umol/24u (16-62)
Phenylalanine: 30 umol/24u (31 - 95)
Tyrosine: 36 umol/24u (40 - 168)
Phosphoethanolamine: 16 umol/24u (19 - 55)
1-methylhistidine: 973 umol/24u (128 - 392)

Normal are:
Anserine: 28 umol/24u ( 0 - 46)
Carnosine: 25 umol/24u ( 0 - 98)
beta-alanine: 25 umol/24u ( 0 - 51)

I have read that when 1-methylhistidine is elevated, then it could be a leaky gut, source: (http://www.aminoacid....com/blog/?p=11)

 

[Valentijn]

I have read that when 1-methylhistidine is elevated, then it could be a leaky gut, source: (http://www.aminoacid....com/blog/?p=11)

It could be that, if you're not eating a high protein diet.

 

[jason30]

That definitely applies to me because i do not eat much meat and there is not much protein in my diet (yet).

Do you know if the 1-methylhistidine levels could be lowered by intake of amino acid's?

Thanks again.