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Authors: Steven D. Targum, Jeffrey Schappi, Athanasia Koutsouris, Runa Bhaumik, Mark H. Rapaport, Natalie Rasgon, Mark M. Rasenick Published on: January 8, 2022 doi: 10.1038/s41380-021-01399-1 Press Release: Researchers identify biomarker for depression, antidepressant response Abstract

Highlights In silico screen identifies β-sitosterol as a candidate anxiolytic drug β-sitosterol is anxiolytic in both naive and chronically stressed mice β-sitosterol alters the expression of immediate early genes Sub-efficacious doses of β-sitosterol and fluoxetine synergize when combined...

I found this research from Dr. Farid Jalali, and it finally explains why severe COVID-19 is so severe despite antivirals and immune suppressants. It's all driven by serotonin from destroyed platelets. I'm mentioning this because it can also explain the damage to the Blood-Brain Barrier (BBB)...