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  1. S

    Aceytl L-carnitine carnitine + melatonin - long term use

    I use both for insomnia, the L-aceytl carnitine helps the wired but tired sensations that keep me restless and awake. Any of you using these long term? Do they remain effective or do you find you need dose increases? 2 x 500mg Acetyl L-carnitine but used to be one 3mg melatonin Reluctant...
  2. P

    Role of EZH2 in ME/ CFS and POTS

    Hi, I have been a silent reader of this forum for many years. During the past couple of months, I often had to think about a study from Australia. There, it is said, that POTS (at least in a subgroup) is caused by an epigenetic malfunction of the NE-Transporter. This epigenetic malfunction can...
  3. SeanQHX1

    Cyclical Alternating Insomnia/Sleeping

    Hi everyone again! I can't say I've had much to report regarding my illness, it's been more of the same, only increasingly worse as time progresses with most of my symptoms. But recently my insomnia seems to have went from week long episodes to a more chronic/intermittent state. Before, there...
  4. C

    Melatonin supplementation improve mitochondrial function - more than just sleep.

    This 2019 study is free to access. Mitochondrial Dysfunction in Skeletal Muscle of a Fibromyalgia Model: The Potential Benefits of Melatonin ( https://www.mdpi.com/1422-0067/20/3/765 ) Discussion points of study - melatonin is: "useful to improve mitochondrial performance" "antioxidative"...