• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.


  1. Bansaw

    Acetylcholine - How do POTS sufferers maintain good levels of it ?

    As a POTS sufferer I am trying to maintain a good level of acetylcholine to help boost cognitive function. I've found Acetyl-l-Carnitine plus a source of choline to be really helpful. However, my body seems to have developed a tolerance for it, even though I do 3 days on, 3 days off to avoid...
  2. R

    PON1 mutations, Excess acetylcholine, excess Adrenaline

    I have realized a lot of my problems have been due to excess acetylcholine. SSRI'S are anticholinergic so they helped me to great extent but not completely. However SSRI'S only target the muscarnic receptors and not the nicotine receptors. I realized that nicotine, acetylcholine and ethanol...