Which B12 to use for methylation based on my genes

[dynamis]

I have been reading about methylation protocol at http://howirecovered.com/active-b12-therapy-faq/ which is a condensed "B-12 hidden story" thread.
I ordered all the supplements and I'm waiting for them to arrive, but just found this page http://www.methyl-life.com/best-form-of-b12.html which got me confused about which B12 to use.

I'm
COMT V158M +/-
VDR Taq +/-

I was planning to start with adB12 first and add mB12 later, but according to this site i should avoid mB12 and use hydroxy and adenosylB12.

Few years ago while i had more energy and felt better i used Jarrow mB12 5000mcg and it used to make me drowsy. Now 1/4 of the pill (which is 1250mcg) makes me hyperactive and agitated.
But i found that i can tolerate 500 mcg sublingual from other manufacturer (pharmaceutical methylB12 in Europe) but it gives me some brain fog. Not sure if this is a detox/startup symptom?
Also I've tried SAMe and it relieves my constant tension but it makes me drowsy, seems to be too serotonergic for me.

In adition
MTHFR C677T -/-
MTHFR A1298C +/-


Any help on B12 is appreciated

 

[Snowdrop]

There's this for A1298C: http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutations/2011/11/30/
C677T: http://mthfr.net/mthfr-c677t-mutation-basic-protocol/2012/02/24/

Many have been down this path. And while we are all a little or a lot different in response I think a few things can be learned as a general rule of thumb.

There are things that need to be done before methylation is started. Others might have ideas but I would consider Supplementing Magnesium, Vitamin C a multi mineral and maybe a very low dose multi B first. Anything that will support the methylation once you start supplementing for it.

This might be more controversial, If you start to get any positive results after a while you should take a break from taking supplements and reassess what you take. It may be that your body is requiring something different from what it needed initially.

Also take a break if you are having a hard time with the supplements. If you are not well, at least in my experience you can make bad judgments with how to continue to proceed. I guess this depends on how ill you are though.

 

[dynamis]

Thanks for the links, i already saw these but they say nothing about type of B12, or are you suggesting that methylation might not be for me at all (as it could be implied from http://mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutations/2011/11/30/ )

I have been experimenting with supplements for 10 years and have tried close to 100 different ones.

Magnesium, Vit C, multivit, minerals, potassium etc etc are already part of my daily routine.

 

[Snowdrop]

Well, there's no magic bullet here. A few people get lucky (in part from endless research and trial).
Not knowing what you have or haven't done it's hard to respond.

I know I couldn't tolerate MB12 so I took hydroxyB12 for some time (AOR brand I think). The results are confounded by the fact that I was taking MTHF at the same time.

If I was doing it now I'd separate them out. This isn't likely what some would recommend.
But I'd start on HB12 for a while then trial some MTHF and see how that goes. And if you've been taking the 'support' supp's for some time I'd probably drop those too and start adding them back in after a month.

I'm going on my own experience here but one of the problems with supplementing is the impatience factor. I want it to work and I want it to work now. So I hit this thing with all I've got.

 

[dynamis]

Impatience is my biggest issue as well I try tons of supplements at once, and of course fail...then i try half of it (wich is still a lot) and fail....

Well i'm going to try mB12 because i already ordered and it takes 3 week from iherb to ship to my country, so i'll try hydroxy if mB12 fails.