@Kimsie , I appreciate your theory about overmethylation.
While reading through this thread some things came to mind. It is a different way of possibly looking at the subject, but I am not up to speed on this with you and Nandixon.
When reading in the methylation forum when I first came here I noticed that more than one person had difficulty with methylfolate and at least one person said they developed Parkinsonian symptoms.
While reading about aldehyde dehydrogenase I found that: "Aldehyde dehydrogenase: The 3
substrates of this enzyme are
aldehyde,
NAD+, and
H2O,"
Aldehyde dehydrogenase peculiarities in Parkinson's.
ALDH + Parkinson's
http://www.ncbi.nlm.nih.gov/pubmed/25298080
Could a pathogen such as candida be causing high levels of aldehydes and causing this sort of combination?
Folate, alcohol, ALDH polymorphism
http://www.ncbi.nlm.nih.gov/pubmed/21946912
Biotin deficiency causes heme deficiency:
http://jn.nutrition.org/content/137/1/25.full
Getting more interesting as I go along!
Epigenetic synergies between biotin and folate in the regulation of pro-inflammatory cytokines and repeats.
http://www.ncbi.nlm.nih.gov/pubmed/24007195
I don't want to go overboard, although I probably already did, but there is also the biotin suppressing fungal candida which would cut down on aldehydes, biotin helping Parkinson Disease, possible relationship of fungal pathogen to pyroluria.
I am only looking for helpful criticism of this information being helpful for the overall theory that you are wondering about.
Edit in:
http://www.alternativementalhealth....ia-bipolar-depression-and-anxiety-symptoms-4/
with respect to biotin:"Preliminary data from Austria (Lauda) demonstrate a modest negative correlation between red cell glutathione and urinary Mauve by colorimetric assay. A significant inverse correlation exists between GST and urinary Mauve by colorimetric assay, and pends publication (correlation coefficient -0.65087, p<0.02). Audhya found very strong inverse correlation (coefficient -0.973) between OHHPL by HPLC/MS and biotin concentration, also pending publication. It is observed that biotinidase, which maintains biotin levels, is very sensitive to oxidative stress."