Hi, As some of you know I post on behalf of my wife who is not up to typing and crafting sentences (such as mine are...), of late she has continued her decline, at most sitting up for half an hour a day. Another dreadful consequence is the continuing degradation of her sleep. She is unable to stay asleep like she used to and achieve the necessary amount to avoid exacerbating her symptoms the following day (often fainting or being unable to move at the end of a day). She can't get to sleep without her nightly drugs and is light sleeping more and more in the early morning. She currently takes -Seroquel (every night) -Melatonin (every night) -Endep (amitriptyline)(every night) -Paxam (most nights) -Stillnox (occasionally for fear of tolerance) -Valium (occasionally to KO her when she can't get back to sleep) So she feels very cornered and desperate, knowing that she can't keep upping these medications or indeed using them every night. So we're asking the forum of fellow sufferers to see what you might recommend to help change it up or cycle through. What has worked for you with such severe symptoms and lack of sleep? We appreciate any good suggestions although she's never had much luck with herbal or alternative options. She has POTS and Leaky gut, is extremely sensitive to foods and some medications and we are also easing her into a treatment of Low Dose Valcyte, hoping to avoid the side effects this time. Thanks!